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Non-human primate models of human respiratory infections
Respiratory pathogens represent a great burden for humanity and a potential source of new pandemics, as illustrated by the recent emergence of coronavirus disease 2019 (COVID-19). In recent decades, biotechnological advances have led to the development of numerous innovative therapeutic molecules an...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062575/ https://www.ncbi.nlm.nih.gov/pubmed/33895579 http://dx.doi.org/10.1016/j.molimm.2021.04.010 |
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author | Lemaitre, Julien Naninck, Thibaut Delache, Benoît Creppy, Justina Huber, Philippe Holzapfel, Marion Bouillier, Camille Contreras, Vanessa Martinon, Frédéric Kahlaoui, Nidhal Pascal, Quentin Tricot, Sabine Ducancel, Frédéric Vecellio, Laurent Le Grand, Roger Maisonnasse, Pauline |
author_facet | Lemaitre, Julien Naninck, Thibaut Delache, Benoît Creppy, Justina Huber, Philippe Holzapfel, Marion Bouillier, Camille Contreras, Vanessa Martinon, Frédéric Kahlaoui, Nidhal Pascal, Quentin Tricot, Sabine Ducancel, Frédéric Vecellio, Laurent Le Grand, Roger Maisonnasse, Pauline |
author_sort | Lemaitre, Julien |
collection | PubMed |
description | Respiratory pathogens represent a great burden for humanity and a potential source of new pandemics, as illustrated by the recent emergence of coronavirus disease 2019 (COVID-19). In recent decades, biotechnological advances have led to the development of numerous innovative therapeutic molecules and vaccine immunogens. However, we still lack effective treatments and vaccines against many respiratory pathogens. More than ever, there is a need for a fast, predictive, preclinical pipeline, to keep pace with emerging diseases. Animal models are key for the preclinical development of disease management strategies. The predictive value of these models depends on their ability to reproduce the features of the human disease, the mode of transmission of the infectious agent and the availability of technologies for monitoring infection. This review focuses on the use of non-human primates as relevant preclinical models for the development of prevention and treatment for human respiratory infections. |
format | Online Article Text |
id | pubmed-8062575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Authors. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80625752021-04-23 Non-human primate models of human respiratory infections Lemaitre, Julien Naninck, Thibaut Delache, Benoît Creppy, Justina Huber, Philippe Holzapfel, Marion Bouillier, Camille Contreras, Vanessa Martinon, Frédéric Kahlaoui, Nidhal Pascal, Quentin Tricot, Sabine Ducancel, Frédéric Vecellio, Laurent Le Grand, Roger Maisonnasse, Pauline Mol Immunol Article Respiratory pathogens represent a great burden for humanity and a potential source of new pandemics, as illustrated by the recent emergence of coronavirus disease 2019 (COVID-19). In recent decades, biotechnological advances have led to the development of numerous innovative therapeutic molecules and vaccine immunogens. However, we still lack effective treatments and vaccines against many respiratory pathogens. More than ever, there is a need for a fast, predictive, preclinical pipeline, to keep pace with emerging diseases. Animal models are key for the preclinical development of disease management strategies. The predictive value of these models depends on their ability to reproduce the features of the human disease, the mode of transmission of the infectious agent and the availability of technologies for monitoring infection. This review focuses on the use of non-human primates as relevant preclinical models for the development of prevention and treatment for human respiratory infections. The Authors. Published by Elsevier Ltd. 2021-07 2021-04-23 /pmc/articles/PMC8062575/ /pubmed/33895579 http://dx.doi.org/10.1016/j.molimm.2021.04.010 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Lemaitre, Julien Naninck, Thibaut Delache, Benoît Creppy, Justina Huber, Philippe Holzapfel, Marion Bouillier, Camille Contreras, Vanessa Martinon, Frédéric Kahlaoui, Nidhal Pascal, Quentin Tricot, Sabine Ducancel, Frédéric Vecellio, Laurent Le Grand, Roger Maisonnasse, Pauline Non-human primate models of human respiratory infections |
title | Non-human primate models of human respiratory infections |
title_full | Non-human primate models of human respiratory infections |
title_fullStr | Non-human primate models of human respiratory infections |
title_full_unstemmed | Non-human primate models of human respiratory infections |
title_short | Non-human primate models of human respiratory infections |
title_sort | non-human primate models of human respiratory infections |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062575/ https://www.ncbi.nlm.nih.gov/pubmed/33895579 http://dx.doi.org/10.1016/j.molimm.2021.04.010 |
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