Wnt5a enhances proliferation of chronic lymphocytic leukemia and ERK1/2 phosphorylation via a ROR1/DOCK2-dependent mechanism

Patients with chronic lymphocytic leukemia (CLL) have high plasma-levels of Wnt5a, which can induce phosphorylation of ERK1/2 and enhance CLL-cell proliferation. Such effects could be inhibited by treatment with an ERK1/2 inhibitor, ERK1/2-specific siRNA, or cirmtuzumab, an anti-ROR1 mAb. The CLL-de...

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Detalles Bibliográficos
Autores principales: Hasan, Md Kamrul, Ghia, Emanuela M., Rassenti, Laura Z., Widhopf, George F., Kipps, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062590/
https://www.ncbi.nlm.nih.gov/pubmed/33097837
http://dx.doi.org/10.1038/s41375-020-01055-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062590/
https://www.ncbi.nlm.nih.gov/pubmed/33097837
http://dx.doi.org/10.1038/s41375-020-01055-7

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