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Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer

Immune checkpoint blockade (ICB) therapy has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment, but <20% of patients achieve durable responses. Persistent activation of the PI3K/AKT/mTOR signaling circuitry represents a key oncogenic driver in HNSCC; however, the potential im...

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Detalles Bibliográficos
Autores principales:	Wang, Zhiyong, Goto, Yusuke, Allevato, Michael M., Wu, Victoria H., Saddawi-Konefka, Robert, Gilardi, Mara, Alvarado, Diego, Yung, Bryan S., O’Farrell, Aoife, Molinolo, Alfredo A., Duvvuri, Umamaheswar, Grandis, Jennifer R., Califano, Joseph A., Cohen, Ezra E. W., Gutkind, J. Silvio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062674/ https://www.ncbi.nlm.nih.gov/pubmed/33888713 http://dx.doi.org/10.1038/s41467-021-22619-w

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