Cargando…

TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer

The treatment and prognosis of advanced colorectal cancer (CRC) remain a challenging clinical research focus. Here, we describe a new CRC tumor suppressor and potential therapeutic target: thymocyte selection associated high mobility group box (TOX) protein. The expression of TOX was lower in CRC th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Mengdi, Huang, Qianru, Li, Changcan, Jiang, Zhiyuan, Sun, Jing, Wang, Zhiyu, Liang, Rui, Li, Dan, Li, Bin, Zhao, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062716/ https://www.ncbi.nlm.nih.gov/pubmed/33897695 http://dx.doi.org/10.3389/fimmu.2021.647540

Ejemplares similares

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
por: Villar, Victor H., et al.
Publicado: (2017)

The mTOR Deficiency in Monocytic Myeloid-Derived Suppressor Cells Protects Mouse Cardiac Allografts by Inducing Allograft Tolerance
por: Li, Jiawei, et al.
Publicado: (2021)

EMP2 acts as a suppressor of melanoma and is negatively regulated by mTOR-mediated autophagy
por: Wang, Manyi, et al.
Publicado: (2019)

All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells
por: Gamper, Christopher J., et al.
Publicado: (2012)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

mTOR Regulation of Lymphoid Cells in Immunity to Pathogens
por: Keating, Rachael, et al.
Publicado: (2016)

mTOR at the Transmitting and Receiving Ends in Tumor Immunity
por: Guri, Yakir, et al.
Publicado: (2018)

mTOR Links Environmental Signals to T Cell Fate Decisions
por: Chapman, Nicole M., et al.
Publicado: (2015)

Inhibition of NLRP3 Inflammasome Activation and Pyroptosis in Macrophages by Taraxasterol Is Associated With Its Regulation on mTOR Signaling
por: Yang, Fan, et al.
Publicado: (2021)

mTOR-Mediated Regulation of Immune Responses in Cancer and Tumor Microenvironment
por: Mafi, Sahar, et al.
Publicado: (2022)

Activity of granulomatosis with polyangiitis and its correlation with mTOR phosphoproteomics in neutrophils
por: Surmiak, Marcin, et al.
Publicado: (2023)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways
por: Bai, Shiyu, et al.
Publicado: (2023)

Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
por: Li, Liuran, et al.
Publicado: (2021)

mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression
por: Kon, Ning, et al.
Publicado: (2021)

mTOR pathway in colorectal cancer: an update
por: Francipane, Maria Giovanna, et al.
Publicado: (2013)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

FGF14 Functions as a Tumor Suppressor through Inhibiting PI3K/AKT/mTOR Pathway in Colorectal Cancer
por: Su, Tianhong, et al.
Publicado: (2020)

AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV
por: Bhatt, Aadra P., et al.
Publicado: (2013)

Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment
por: Howie, Duncan, et al.
Publicado: (2014)

Regulation of RLR-Mediated Antiviral Responses of Human Dendritic Cells by mTOR
por: Fekete, Tünde, et al.
Publicado: (2020)

mTOR Signaling in the Regulation of CD4+ T Cell Subsets in Periodontal Diseases
por: Jiang, Qian, et al.
Publicado: (2022)

The Coordination of mTOR Signaling and Non-Coding RNA in Regulating Epileptic Neuroinflammation
por: Zeng, Chudai, et al.
Publicado: (2022)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
por: Tian, Tian, et al.
Publicado: (2019)

mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors
por: Wu, Tingting, et al.
Publicado: (2016)

miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR
por: Li, Wenhua, et al.
Publicado: (2015)

Resident-Memory CD8 T Cells and mTOR: Generation, Protection, and Clinical Importance
por: Sowell, Ryan T., et al.
Publicado: (2015)

Serine Supports IL-1β Production in Macrophages Through mTOR Signaling
por: Chen, Siyuan, et al.
Publicado: (2020)

Activated mTOR signaling pathway in myofibers with inherited metabolic defect might be an evidence for mTOR inhibition therapies
por: Lyu, Jing-Wei, et al.
Publicado: (2019)

Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation
por: Welte, Thomas, et al.
Publicado: (2016)

mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo
por: Chen, Sijia, et al.
Publicado: (2020)

mTOR Signaling Pathway Regulates the Release of Proinflammatory Molecule CCL5 Implicated in the Pathogenesis of Autism Spectrum Disorder
por: Wang, Baojiang, et al.
Publicado: (2022)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue
por: Wada, Shogo, et al.
Publicado: (2016)

IFN-γ mediates Paneth cell death via suppression of mTOR
por: Araujo, Alessandra, et al.
Publicado: (2021)

The Prognostic Role of mTOR and P-mTOR for Survival in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
por: Li, Lei, et al.
Publicado: (2015)

Keratoacanthoma of the Lip: Activation of the mTOR Pathway, Tumor Suppressor Proteins, and Tumor Senescence
por: Dillenburg, Caroline Siviero, et al.
Publicado: (2015)

Cortisol inhibits mTOR signaling in avascular necrosis of the femoral head
por: Liao, Yun, et al.
Publicado: (2017)

The host mTOR pathway and parasitic diseases pathogenesis
por: Rashidi, Sajad, et al.
Publicado: (2021)

TRPM7 Kinase Is Essential for Neutrophil Recruitment and Function via Regulation of Akt/mTOR Signaling
por: Nadolni, Wiebke, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1cfck1p0f7s8375jcd8usg6eac