Cargando…

Mechanism of the Maturation Process of SARS-CoV 3CL Protease

Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel human coronavirus. Viral maturation requires a main protease (3CL(pro)) to cleave the virus-encoded polyproteins. We report here that the 3CL(pro) containing additional N- and/or C-terminal segments of the p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hsu, Min-Feng, Kuo, Chih-Jung, Chang, Kai-Ti, Chang, Hui-Chuan, Chou, Chia-Cheng, Ko, Tzu-Ping, Shr, Hui-Lin, Chang, Gu-Gang, Wang, Andrew H.-J., Liang, Po-Huang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 2005
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062786/ https://www.ncbi.nlm.nih.gov/pubmed/15788388 http://dx.doi.org/10.1074/jbc.M502577200

Ejemplares similares

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL(pro)): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS
por: Tomar, Sakshi, et al.
Publicado: (2015)

Molecular Recognition of Chymotrypsin by the Serine Protease Inhibitor Ecotin from Yersinia pestis
por: Clark, Elizabeth A., et al.
Publicado: (2011)

Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation
por: Grishkovskaya, Irina, et al.
Publicado: (2017)

Dissection Study on the Severe Acute Respiratory Syndrome 3C-like Protease Reveals the Critical Role of the Extra Domain in Dimerization of the Enzyme: DEFINING THE EXTRA DOMAIN AS A NEW TARGET FOR DESIGN OF HIGHLY SPECIFIC PROTEASE INHIBITORS
por: Shi, Jiahai, et al.
Publicado: (2004)

Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity
por: Fieulaine, Sonia, et al.
Publicado: (2020)

α(2)-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester
por: Harwood, Seandean Lykke, et al.
Publicado: (2021)

Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease: CRYSTAL STRUCTURE WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2008)

Electron microscopy snapshots of single particles from single cells
por: Yi, Xiunan, et al.
Publicado: (2019)

Structural and Functional Studies of a Newly Grouped Haloquadratum walsbyi Bacteriorhodopsin Reveal the Acid-resistant Light-driven Proton Pumping Activity
por: Hsu, Min-Feng, et al.
Publicado: (2015)

Synaptotagmin C2B Domain Regulates Ca(2+)-triggered Fusion in Vitro: CRITICAL RESIDUES REVEALED BY SCANNING ALANINE MUTAGENESIS
por: Gaffaney, Jon D., et al.
Publicado: (2008)

Crystal Structure of Severe Acute Respiratory Syndrome Coronavirus Spike Protein Fusion Core
por: Xu, Yanhui, et al.
Publicado: (2004)

Macro Domain from Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Is an Efficient ADP-ribose Binding Module: CRYSTAL STRUCTURE AND BIOCHEMICAL STUDIES
por: Cho, Chao-Cheng, et al.
Publicado: (2016)

Structural Basis for Coronavirus-mediated Membrane Fusion: CRYSTAL STRUCTURE OF MOUSE HEPATITIS VIRUS SPIKE PROTEIN FUSION CORE
por: Xu, Yanhui, et al.
Publicado: (2004)

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini
por: Ouyang, Hui, et al.
Publicado: (2012)

Plasticity of Human Protein Disulfide Isomerase: EVIDENCE FOR MOBILITY AROUND THE X-LINKER REGION AND ITS FUNCTIONAL SIGNIFICANCE
por: Wang, Chao, et al.
Publicado: (2010)

Structural Basis of Rnd1 Binding to Plexin Rho GTPase Binding Domains (RBDs)
por: Wang, Hui, et al.
Publicado: (2011)

The Truncated C-terminal RNA Recognition Motif of TDP-43 Protein Plays a Key Role in Forming Proteinaceous Aggregates
por: Wang, Yi-Ting, et al.
Publicado: (2013)

Fibulin 5 Forms a Compact Dimer in Physiological Solutions
por: Jones, Richard P. O., et al.
Publicado: (2009)

A Novel Cofactor-binding Mode in Bacterial IMP Dehydrogenases Explains Inhibitor Selectivity
por: Makowska-Grzyska, Magdalena, et al.
Publicado: (2015)

APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes
por: Pardossi-Piquard, Raphaëlle, et al.
Publicado: (2009)

Reversible Unfolding of the Severe Acute Respiratory Syndrome Coronavirus Main Protease in Guanidinium Chloride
por: Chang, Hui-Ping, et al.
Publicado: (2007)

Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization: BIOCHEMICAL AND THERMODYNAMIC INVESTIGATION IN CONJUNCTION WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2005)

Recombinant Severe Acute Respiratory Syndrome (SARS) Coronavirus Nucleocapsid Protein Forms a Dimer through Its C-terminal Domain
por: Yu, I-Mei, et al.
Publicado: (2005)

Structure of the N-terminal Region of Complement Factor H and Conformational Implications of Disease-linked Sequence Variations
por: Hocking, Henry G., et al.
Publicado: (2008)

Crystal Structure of a Functional Dimer of the PhoQ Sensor Domain
por: Cheung, Jonah, et al.
Publicado: (2008)

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme
por: Carlson, Brian L., et al.
Publicado: (2008)

Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells
por: Gomes, Mariana P. B., et al.
Publicado: (2008)

Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90
por: Cunningham, Christian N., et al.
Publicado: (2008)

A Common Theme in Interaction of Bacterial Immunoglobulin-binding Proteins with Immunoglobulins Illustrated in the Equine System
por: Lewis, Melanie J., et al.
Publicado: (2008)

A Common β-Sheet Architecture Underlies in Vitro and in Vivo β(2)-Microglobulin Amyloid Fibrils
por: Jahn, Thomas R., et al.
Publicado: (2008)

Appearance and Propagation of Polyglutamine-based Amyloids in Yeast: TYROSINE RESIDUES ENABLE POLYMER FRAGMENTATION
por: Alexandrov, Ilya M., et al.
Publicado: (2008)

Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia
por: Grummitt, Charles G., et al.
Publicado: (2008)

Structure of the Human 26S Proteasome: SUBUNIT RADIAL DISPLACEMENTS OPEN THE GATE INTO THE PROTEOLYTIC CORE
por: da Fonseca, Paula C. A., et al.
Publicado: (2008)

Crystal Structure of Colicin M, a Novel Phosphatase Specifically Imported by Escherichia coli>
por: Zeth, Kornelius, et al.
Publicado: (2008)

Structure-Function Analysis of the C3 Binding Region of Staphylococcus aureus Immune Subversion Protein Sbi
por: Upadhyay, Abhishek, et al.
Publicado: (2008)

Structural Constraints for the Binding of Short Peptides to Claudin-4 Revealed by Surface Plasmon Resonance
por: Ling, Jun, et al.
Publicado: (2008)

Electrostatic and Lipid Anchor Contributions to the Interaction of Transducin with Membranes: MECHANISTIC IMPLICATIONS FOR ACTIVATION AND TRANSLOCATION
por: Kosloff, Mickey, et al.
Publicado: (2008)

Albumin-conjugated C34 Peptide HIV-1 Fusion Inhibitor: EQUIPOTENT TO C34 AND T-20 IN VITRO WITH SUSTAINED ACTIVITY IN SCID-HU THY/LIV MICE
por: Stoddart, Cheryl A., et al.
Publicado: (2008)

Deciphering the Ligand-binding Sites in the Borrelia burgdorferi Complement Regulator-acquiring Surface Protein 2 Required for Interactions with the Human Immune Regulators Factor H and Factor H-like Protein 1
por: Siegel, Corinna, et al.
Publicado: (2008)

Iron-mediated Aggregation and a Localized Structural Change Characterize Ferritin from a Mutant Light Chain Polypeptide That Causes Neurodegeneration
por: Baraibar, Martin A., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_8dink8kmnihqhevudanvhm0nqf