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Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. Studies have shown that MS disrupts several social cognitive abilities [including empathy and theory of mind (ToM)]. Overall ToM deficits in MS are well documented, but how the specific ToM subcomponen...

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Autores principales: Lin, XiaoGuang, Zhang, XueLing, Liu, QinQin, Zhao, PanWen, Zhong, JianGuo, Pan, PingLei, Wang, GenDi, Yi, ZhongQuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062809/
https://www.ncbi.nlm.nih.gov/pubmed/33897490
http://dx.doi.org/10.3389/fpsyt.2021.628110
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author Lin, XiaoGuang
Zhang, XueLing
Liu, QinQin
Zhao, PanWen
Zhong, JianGuo
Pan, PingLei
Wang, GenDi
Yi, ZhongQuan
author_facet Lin, XiaoGuang
Zhang, XueLing
Liu, QinQin
Zhao, PanWen
Zhong, JianGuo
Pan, PingLei
Wang, GenDi
Yi, ZhongQuan
author_sort Lin, XiaoGuang
collection PubMed
description Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. Studies have shown that MS disrupts several social cognitive abilities [including empathy and theory of mind (ToM)]. Overall ToM deficits in MS are well documented, but how the specific ToM subcomponents and empathic capacity are affected remains unclear. For this meta-analysis, we searched PubMed, Web of Science, and Embase from inception to July 2020. Effect sizes were calculated using Hedges g with a random-effects model. Thirty-three studies were included. Relative to healthy controls (HCs), patients with MS were moderately impaired in overall empathy (g = −0.67), overall ToM (g = −74), cognitive ToM (g = −0.72), and the overlapping domains of cognitive empathy/affective ToM (g = −0.79); no group differences were identified for affective empathy (g = −0.19). Compared with HCs, patients with relapsing-remitting MS (RRMS) and progressive MS were impaired in overall empathy, overall ToM, cognitive ToM, and cognitive empathy/affective ToM, without significant RRMS–progressive MS differences in impairment degree. We conducted the first meta-analytic review investigating the empathy and ToM functioning patterns in patients with MS and examined the overlapping and distinct subcomponents of these constructs. The findings suggest differential impairment of the core aspects of social cognitive processing in patients with MS, which may importantly inform the development of structured social cognitive MS interventions.
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spelling pubmed-80628092021-04-24 Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis Lin, XiaoGuang Zhang, XueLing Liu, QinQin Zhao, PanWen Zhong, JianGuo Pan, PingLei Wang, GenDi Yi, ZhongQuan Front Psychiatry Psychiatry Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. Studies have shown that MS disrupts several social cognitive abilities [including empathy and theory of mind (ToM)]. Overall ToM deficits in MS are well documented, but how the specific ToM subcomponents and empathic capacity are affected remains unclear. For this meta-analysis, we searched PubMed, Web of Science, and Embase from inception to July 2020. Effect sizes were calculated using Hedges g with a random-effects model. Thirty-three studies were included. Relative to healthy controls (HCs), patients with MS were moderately impaired in overall empathy (g = −0.67), overall ToM (g = −74), cognitive ToM (g = −0.72), and the overlapping domains of cognitive empathy/affective ToM (g = −0.79); no group differences were identified for affective empathy (g = −0.19). Compared with HCs, patients with relapsing-remitting MS (RRMS) and progressive MS were impaired in overall empathy, overall ToM, cognitive ToM, and cognitive empathy/affective ToM, without significant RRMS–progressive MS differences in impairment degree. We conducted the first meta-analytic review investigating the empathy and ToM functioning patterns in patients with MS and examined the overlapping and distinct subcomponents of these constructs. The findings suggest differential impairment of the core aspects of social cognitive processing in patients with MS, which may importantly inform the development of structured social cognitive MS interventions. Frontiers Media S.A. 2021-04-09 /pmc/articles/PMC8062809/ /pubmed/33897490 http://dx.doi.org/10.3389/fpsyt.2021.628110 Text en Copyright © 2021 Lin, Zhang, Liu, Zhao, Zhong, Pan, Wang and Yi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Lin, XiaoGuang
Zhang, XueLing
Liu, QinQin
Zhao, PanWen
Zhong, JianGuo
Pan, PingLei
Wang, GenDi
Yi, ZhongQuan
Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis
title Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis
title_full Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis
title_fullStr Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis
title_full_unstemmed Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis
title_short Empathy and Theory of Mind in Multiple Sclerosis: A Meta-Analysis
title_sort empathy and theory of mind in multiple sclerosis: a meta-analysis
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062809/
https://www.ncbi.nlm.nih.gov/pubmed/33897490
http://dx.doi.org/10.3389/fpsyt.2021.628110
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