Cargando…
Diet Quality and Breast Cancer Recurrence and Survival: The Pathways Study
BACKGROUND: Prior research suggests a relationship between overall diet quality and breast cancer survival, although few studies have reported on this topic. We evaluated whether 4 dietary quality indices consistent with healthy eating recommendations around the time of breast cancer diagnosis were...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062847/ https://www.ncbi.nlm.nih.gov/pubmed/33928215 http://dx.doi.org/10.1093/jncics/pkab019 |
_version_ | 1783681848362139648 |
---|---|
author | Ergas, Isaac J Cespedes Feliciano, Elizabeth M Bradshaw, Patrick T Roh, Janise M Kwan, Marilyn L Cadenhead, Jen Santiago-Torres, Margarita Troeschel, Alyssa N Laraia, Barbara Madsen, Kristine Kushi, Lawrence H |
author_facet | Ergas, Isaac J Cespedes Feliciano, Elizabeth M Bradshaw, Patrick T Roh, Janise M Kwan, Marilyn L Cadenhead, Jen Santiago-Torres, Margarita Troeschel, Alyssa N Laraia, Barbara Madsen, Kristine Kushi, Lawrence H |
author_sort | Ergas, Isaac J |
collection | PubMed |
description | BACKGROUND: Prior research suggests a relationship between overall diet quality and breast cancer survival, although few studies have reported on this topic. We evaluated whether 4 dietary quality indices consistent with healthy eating recommendations around the time of breast cancer diagnosis were associated with risk of recurrence, cause-specific, and all-cause mortality. METHODS: A total of 3660 women diagnosed with invasive breast cancer were included. Diet was assessed an average of 2.3 (range = 0.7-18.7) months after diagnosis, from which 4 dietary quality indices were derived: the American Cancer Society guidelines (ACS), the alternate Mediterranean Diet Index (aMED), the Dietary Approaches to Stop Hypertension (DASH), and the 2015 Healthy Eating Index (HEI). Over 40 888 person-years of follow-up, 461 breast cancer recurrences, and 655 deaths were ascertained. Cox models were used to estimate hazards ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Adjusted comparisons between extreme quintiles showed all 4 dietary quality indices to be inversely associated with all-cause mortality, suggesting a 21%-27% lower risk (ACS HR = 0.73, 95% CI = 0.56 to 0.95; aMED HR = 0.79, 95% CI = 0.61 to 1.03; DASH HR = 0.76, 95% CI = 0.58 to 1.00; HEI HR = 0.77, 95% CI = 0.60 to 1.01). Similar patterns were noted for non-breast cancer mortality (ACS HR = 0.69, 95% CI = 0.48 to 0.98; aMED HR = 0.73, 95% CI = 0.50 to 1.05; DASH HR = 0.55, 95% CI = 0.38 to 0.79; HEI HR = 0.67, 95% CI = 0.48 to 0.94). None of the dietary quality indices were associated with recurrence or breast cancer–specific mortality. CONCLUSION: Food intake patterns concordant with dietary quality indices consistent with recommendations for healthy eating may be beneficial for women with breast cancer. |
format | Online Article Text |
id | pubmed-8062847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-80628472021-04-28 Diet Quality and Breast Cancer Recurrence and Survival: The Pathways Study Ergas, Isaac J Cespedes Feliciano, Elizabeth M Bradshaw, Patrick T Roh, Janise M Kwan, Marilyn L Cadenhead, Jen Santiago-Torres, Margarita Troeschel, Alyssa N Laraia, Barbara Madsen, Kristine Kushi, Lawrence H JNCI Cancer Spectr Article BACKGROUND: Prior research suggests a relationship between overall diet quality and breast cancer survival, although few studies have reported on this topic. We evaluated whether 4 dietary quality indices consistent with healthy eating recommendations around the time of breast cancer diagnosis were associated with risk of recurrence, cause-specific, and all-cause mortality. METHODS: A total of 3660 women diagnosed with invasive breast cancer were included. Diet was assessed an average of 2.3 (range = 0.7-18.7) months after diagnosis, from which 4 dietary quality indices were derived: the American Cancer Society guidelines (ACS), the alternate Mediterranean Diet Index (aMED), the Dietary Approaches to Stop Hypertension (DASH), and the 2015 Healthy Eating Index (HEI). Over 40 888 person-years of follow-up, 461 breast cancer recurrences, and 655 deaths were ascertained. Cox models were used to estimate hazards ratios (HRs) and 95% confidence intervals (CIs). RESULTS: Adjusted comparisons between extreme quintiles showed all 4 dietary quality indices to be inversely associated with all-cause mortality, suggesting a 21%-27% lower risk (ACS HR = 0.73, 95% CI = 0.56 to 0.95; aMED HR = 0.79, 95% CI = 0.61 to 1.03; DASH HR = 0.76, 95% CI = 0.58 to 1.00; HEI HR = 0.77, 95% CI = 0.60 to 1.01). Similar patterns were noted for non-breast cancer mortality (ACS HR = 0.69, 95% CI = 0.48 to 0.98; aMED HR = 0.73, 95% CI = 0.50 to 1.05; DASH HR = 0.55, 95% CI = 0.38 to 0.79; HEI HR = 0.67, 95% CI = 0.48 to 0.94). None of the dietary quality indices were associated with recurrence or breast cancer–specific mortality. CONCLUSION: Food intake patterns concordant with dietary quality indices consistent with recommendations for healthy eating may be beneficial for women with breast cancer. Oxford University Press 2021-03-02 /pmc/articles/PMC8062847/ /pubmed/33928215 http://dx.doi.org/10.1093/jncics/pkab019 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Article Ergas, Isaac J Cespedes Feliciano, Elizabeth M Bradshaw, Patrick T Roh, Janise M Kwan, Marilyn L Cadenhead, Jen Santiago-Torres, Margarita Troeschel, Alyssa N Laraia, Barbara Madsen, Kristine Kushi, Lawrence H Diet Quality and Breast Cancer Recurrence and Survival: The Pathways Study |
title | Diet Quality and Breast Cancer Recurrence and Survival: The Pathways Study |
title_full | Diet Quality and Breast Cancer Recurrence and Survival: The Pathways Study |
title_fullStr | Diet Quality and Breast Cancer Recurrence and Survival: The Pathways Study |
title_full_unstemmed | Diet Quality and Breast Cancer Recurrence and Survival: The Pathways Study |
title_short | Diet Quality and Breast Cancer Recurrence and Survival: The Pathways Study |
title_sort | diet quality and breast cancer recurrence and survival: the pathways study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062847/ https://www.ncbi.nlm.nih.gov/pubmed/33928215 http://dx.doi.org/10.1093/jncics/pkab019 |
work_keys_str_mv | AT ergasisaacj dietqualityandbreastcancerrecurrenceandsurvivalthepathwaysstudy AT cespedesfelicianoelizabethm dietqualityandbreastcancerrecurrenceandsurvivalthepathwaysstudy AT bradshawpatrickt dietqualityandbreastcancerrecurrenceandsurvivalthepathwaysstudy AT rohjanisem dietqualityandbreastcancerrecurrenceandsurvivalthepathwaysstudy AT kwanmarilynl dietqualityandbreastcancerrecurrenceandsurvivalthepathwaysstudy AT cadenheadjen dietqualityandbreastcancerrecurrenceandsurvivalthepathwaysstudy AT santiagotorresmargarita dietqualityandbreastcancerrecurrenceandsurvivalthepathwaysstudy AT troeschelalyssan dietqualityandbreastcancerrecurrenceandsurvivalthepathwaysstudy AT laraiabarbara dietqualityandbreastcancerrecurrenceandsurvivalthepathwaysstudy AT madsenkristine dietqualityandbreastcancerrecurrenceandsurvivalthepathwaysstudy AT kushilawrenceh dietqualityandbreastcancerrecurrenceandsurvivalthepathwaysstudy |