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Assessment of a Polygenic Risk Score for Colorectal Cancer to Predict Risk of Lynch Syndrome Colorectal Cancer

It was not known whether the polygenic risk scores (PRSs) that predict colorectal cancer could predict colorectal cancer for people with inherited pathogenic variants in DNA mismatch repair genes—people with Lynch syndrome. We tested a PRS comprising 107 established single-nucleotide polymorphisms a...

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Detalles Bibliográficos
Autores principales:	Jenkins, Mark A, Buchanan, Daniel D, Lai, John, Makalic, Enes, Dite, Gillian S, Win, Aung K, Clendenning, Mark, Winship, Ingrid M, Hayes, Richard B, Huyghe, Jeroen R, Peters, Ulrike, Gallinger, Steven, Marchand, Loïc Le, Figueiredo, Jane C, Pai, Rish K, Newcomb, Polly A, Church, James M, Casey, Graham, Hopper, John L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Brief Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062848/ https://www.ncbi.nlm.nih.gov/pubmed/33928216 http://dx.doi.org/10.1093/jncics/pkab022

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