2-Methoxyestradiol and its derivatives inhibit store-operated Ca(2+) entry in T cells: Identification of a new and potent inhibitor

T cell activation starts with formation of second messengers that release Ca(2+) from the endoplasmic reticulum (ER) and thereby activate store-operated Ca(2+) entry (SOCE), one of the essential signals for T cell activation. Recently, the steroidal 2-methoxyestradiol was shown to inhibit nuclear tr...

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Detalles Bibliográficos
Autores principales: Löhndorf, Anke, Hosang, Leon, Dohle, Wolfgang, Odoardi, Francesca, Waschkowski, Sissy-Alina, Rosche, Anette, Bauche, Andreas, Winzer, Riekje, Tolosa, Eva, Windhorst, Sabine, Marry, Stephen, Flügel, Alexander, Potter, Barry V.L., Diercks, Björn-Philipp, Guse, Andreas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062851/
https://www.ncbi.nlm.nih.gov/pubmed/33581218
http://dx.doi.org/10.1016/j.bbamcr.2021.118988

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