Cargando…
Structure-Based Virtual Screening to Identify Novel Potential Compound as an Alternative to Remdesivir to Overcome the RdRp Protein Mutations in SARS-CoV-2
The number of confirmed COVID-19 cases is rapidly increasing with no direct treatment for the disease. Few repurposed drugs, such as Remdesivir, Chloroquine, Hydroxychloroquine, Lopinavir, and Ritonavir, are being tested against SARS-CoV-2. Remdesivir is the drug of choice for Ebola virus disease an...
Autores principales: | Kumar D, Thirumal, Shaikh, Nishaat, Kumar S, Udhaya, Doss C, George Priya, Zayed, Hatem |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8062963/ https://www.ncbi.nlm.nih.gov/pubmed/33898520 http://dx.doi.org/10.3389/fmolb.2021.645216 |
Ejemplares similares
-
Molecular Dynamics Simulations Reveal the Interaction Fingerprint of Remdesivir Triphosphate Pivotal in Allosteric Regulation of SARS-CoV-2 RdRp
por: Srivastava, Mitul, et al.
Publicado: (2021) -
RdRp or RT, That is the Question
por: Peyambari, Mahtab, et al.
Publicado: (2021) -
Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2
por: Arba, Muhammad, et al.
Publicado: (2021) -
Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides
por: Wang, Bing, et al.
Publicado: (2021) -
Snapshots of a Non-Canonical RdRP in Action
por: Ferrero, Diego S., et al.
Publicado: (2021)