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Olaparib-mediated enhancement of 5-fluorouracil cytotoxicity in mismatch repair deficient colorectal cancer cells

BACKGROUND: The advances in colorectal cancer (CRC) treatment include the identification of deficiencies in Mismatch Repair (MMR) pathway to predict the benefit of adjuvant 5-fluorouracil (5-FU) and oxaliplatin for stage II CRC and immunotherapy. Defective MMR contributes to chemoresistance in CRC....

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Detalles Bibliográficos
Autores principales:	de Castro e Gloria, Helena, Jesuíno Nogueira, Laura, Bencke Grudzinski, Patrícia, da Costa Ghignatti, Paola Victória, Guecheva, Temenouga Nikolova, Motta Leguisamo, Natalia, Saffi, Jenifer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063290/ https://www.ncbi.nlm.nih.gov/pubmed/33888065 http://dx.doi.org/10.1186/s12885-021-08188-7

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