Cargando…

Interaction analysis of statistically enriched mutations identified in Cameroon recombinant subtype CRF02_AG that can influence the development of Dolutegravir drug resistance mutations

BACKGROUND: The Integrase (IN) strand transfer inhibitor (INSTI), Dolutegravir (DTG), has been given the green light to form part of first-line combination antiretroviral therapy (cART) by the World Health Organization (WHO). DTG containing regimens have shown a high genetic barrier against HIV-1 is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mikasi, Sello Given, Isaacs, Darren, Chitongo, Rumbidzai, Ikomey, George Mondide, Jacobs, Graeme Brendon, Cloete, Ruben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063366/ https://www.ncbi.nlm.nih.gov/pubmed/33892628 http://dx.doi.org/10.1186/s12879-021-06059-x

Ejemplares similares

Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding
por: Chitongo, Rumbidzai, et al.
Publicado: (2020)

Correction: Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C Integrase-Dolutegravir binding
por: Chitongo, Rumbidzai, et al.
Publicado: (2020)

Structural Comparison of Diverse HIV-1 Subtypes using Molecular Modelling and Docking Analyses of Integrase Inhibitors
por: Isaacs, Darren, et al.
Publicado: (2020)

Drug Resistance Mutations Against Protease, Reverse Transcriptase and Integrase Inhibitors in People Living With HIV-1 Receiving Boosted Protease Inhibitors in South Africa
por: Obasa, Adetayo Emmanuel, et al.
Publicado: (2020)

Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaoundé, Cameroon
por: Teto, Georges, et al.
Publicado: (2017)

Contrasting antibody responses to intrasubtype superinfection with CRF02_AG
por: Courtney, Colleen R., et al.
Publicado: (2017)

High-Level Drug-Resistant Mutations among HIV-1 Subtype A6 and CRF02_AG in Kazakhstan
por: Sanaubarova, Ainur, et al.
Publicado: (2023)

Near full genome characterization of HIV‐1 unique recombinant forms in Cameroon reveals dominant CRF02_AG and F2 recombination patterns
por: Banin, Andrew N, et al.
Publicado: (2019)

Phylodynamic analysis of HIV-1 subtypes B, C and CRF 02_AG in Senegal
por: Nascimento, Fabrícia F., et al.
Publicado: (2020)

HIV-1 CRF 02 AG polymerase genes in Southern Ghana are mosaics of different 02 AG strains and the protease gene cannot infer subtypes
por: Sagoe, Kwamena W, et al.
Publicado: (2009)

Prevalence and patterns of HIV drug resistance in patients with suspected virological failure in North-Western Tanzania
por: Henerico, Shimba, et al.
Publicado: (2021)

Refined identification of neutralization-resistant CRF02_AG viruses and their sensitivity to anti-MPER neutralizing antibodies
por: Jacob, RA, et al.
Publicado: (2012)

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions
por: Kostaki, Evangelia-Georgia, et al.
Publicado: (2019)

Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa
por: Brado, Dominik, et al.
Publicado: (2018)

Author Correction: Analyses of HIV-1 integrase sequences prior to South African national HIV-treatment program and availability of integrase inhibitors in Cape Town, South Africa
por: Brado, Dominik, et al.
Publicado: (2018)

Genetic Characteristics, Coreceptor Usage Potential and Evolution of Nigerian HIV-1 Subtype G and CRF02_AG Isolates
por: Ajoge, Hannah O., et al.
Publicado: (2011)

Performance of Xpert HIV-1 viral load test in Senegal: a country of high circulation of CRF02_AG
por: Sène, Pauline Yacine, et al.
Publicado: (2022)

In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors
por: Ni, Xiaoju, et al.
Publicado: (2012)

Circulation of HIV-1 CRF02_AG among MSM Population in Central Italy: A Molecular Epidemiology-Based Study
por: Giuliani, Massimo, et al.
Publicado: (2013)

Rate of viral load change and adherence of HIV adult patients treated with Efavirenz or Nevirapine antiretroviral regimens at 24 and 48 weeks in Yaoundé, Cameroon: a longitudinal cohort study
por: Chendi, Bih Hycenta, et al.
Publicado: (2019)

Characterization of a novel HIV-1 circulating recombinant form, CRF91_cpx, comprising CRF02_AG, G, J, and U, mostly among men who have sex with men
por: Topcu, Cicek, et al.
Publicado: (2022)

Characterization of HIV-1 CRF02_AG/A3/G unique recombinant forms identified among children in Larkana, Pakistan
por: Rashid, Abdur, et al.
Publicado: (2023)

The disproportionate effect of COVID-19 mortality on ethnic minorities: Genetics or health inequalities?
por: El-Khatib, Ziad, et al.
Publicado: (2020)

The predominance of Human Immunodeficiency Virus type 1 (HIV-1) circulating recombinant form 02 (CRF02_AG) in West Central Africa may be related to its replicative fitness
por: Njai, Harr F, et al.
Publicado: (2006)

Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies
por: Dieltjens, Tessa, et al.
Publicado: (2009)

Broad Antibody Mediated Cross-Neutralization and Preclinical Immunogenicity of New Codon-Optimized HIV-1 Clade CRF02_AG and G Primary Isolates
por: Agwale, Simon M., et al.
Publicado: (2011)

Phylogeny of partial gag, pol and env genes show predominance of HIV-1G and CRF02_AG with emerging recombinants in south-eastern Nigeria
por: Udeze, Augustine O., et al.
Publicado: (2020)

Female Sex Hormones Upregulate the Replication Activity of HIV-1 Sub-Subtype A6 and CRF02_AG but Not HIV-1 Subtype B
por: Nosik, Marina, et al.
Publicado: (2023)

Probing Resistance Mutations in Retroviral Integrases by Direct Measurement of Dolutegravir Fluorescence
por: Thierry, Eloïse, et al.
Publicado: (2017)

Frequent CXCR4 tropism of HIV-1 subtype A and CRF02_AG during late-stage disease - indication of an evolving epidemic in West Africa
por: Esbjörnsson, Joakim, et al.
Publicado: (2010)

Epigenetics, N-myrystoyltransferase-1 and casein kinase-2-alpha modulates the increased replication of HIV-1 CRF02_AG, compared to subtype-B viruses
por: Bhargavan, Biju, et al.
Publicado: (2019)

Fast Dissemination of New HIV-1 CRF02/A1 Recombinants in Pakistan
por: Chen, Yue, et al.
Publicado: (2016)

Spatiotemporal dynamics of HIV-1 CRF63_02A6 sub-epidemic
por: Sivay, Mariya V., et al.
Publicado: (2022)

Significant contribution of subtype G to HIV-1 genetic complexity in Nigeria identified by a newly developed subtyping assay specific for subtype G and CRF02_AG
por: Heipertz, Richard A., et al.
Publicado: (2016)

Dolutegravir-associated resistance mutations after first-line treatment failure in Brazil
por: Diaz, Ricardo Sobhie, et al.
Publicado: (2023)

First case of Dolutegravir and Darunavir/r multi drug-resistant HIV-1 in Cameroon following exposure to Raltegravir: lessons and implications in the era of transition to Dolutegravir-based regimens
por: Fokam, Joseph, et al.
Publicado: (2020)

Functional analysis of a monoclonal antibody reactive against the C1C2 of Env obtained from a patient infected with HIV-1 CRF02_AG
por: Md Zahid, Hasan, et al.
Publicado: (2021)

Consensus Integrase of a New HIV-1 Genetic Variant CRF63_02A1
por: Agapkina, Y. Y., et al.
Publicado: (2019)

The S68G polymorphism is a compensatory mutation associated with the drug resistance mutation K65R in CRF01_AE strains
por: Li, Shengjia, et al.
Publicado: (2020)

Arcuate AgRP, but not POMC neurons, modulate paraventricular CRF synthesis and release in response to fasting
por: Fernandes, Alan Carlos Alves, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_n5509tpqdrqbo7nl6vdg517v1r