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The complexity of tumour angiogenesis based on recently described molecules
Tumour angiogenesis is a crucial factor associated with tumour growth, progression, and metastasis. The whole process is the result of an interaction between a wide range of different molecules, influencing each other. Herein we summarize novel discoveries related to the less known angiogenic molecu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063899/ https://www.ncbi.nlm.nih.gov/pubmed/33911980 http://dx.doi.org/10.5114/wo.2021.105075 |
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author | Wiśniewska, Weronika Kopka, Michał Siemiątkowska, Karolina Fudalej, Marta Magdalena Sobiborowicz, Aleksandra Badowska-Kozakiewicz, Anna Maria |
author_facet | Wiśniewska, Weronika Kopka, Michał Siemiątkowska, Karolina Fudalej, Marta Magdalena Sobiborowicz, Aleksandra Badowska-Kozakiewicz, Anna Maria |
author_sort | Wiśniewska, Weronika |
collection | PubMed |
description | Tumour angiogenesis is a crucial factor associated with tumour growth, progression, and metastasis. The whole process is the result of an interaction between a wide range of different molecules, influencing each other. Herein we summarize novel discoveries related to the less known angiogenic molecules such as galectins, pentraxin-3, Ral-interacting protein of 76 kDa (RLIP76), long non-coding RNAs (lncRNAs), B7-H3, and delta-like ligand-4 (DLL-4) and their role in the process of tumour angiogenesis. These molecules influence the most important molecular pathways involved in the formation of blood vessels in cancer, including the vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor interaction (VEGFR), HIF1-a activation, or PI3K/Akt/mTOR and JAK-STAT signalling pathways. Increased expression of galectins, RLIP76, and B7H3 has been proven in several malignancies. Pentraxin-3, which appears to inhibit tumour angiogenesis, shows reduced expression in tumour tissues. Anti-angiogenic treatment based mainly on VEGF inhibition has proved to be of limited effectiveness, leading to the development of drug resistance. The newly discovered molecules are of great interest as a potential source of new anti-cancer therapies. Their role as targets for new drugs and as prognostic markers in neoplasms is discussed in this review. |
format | Online Article Text |
id | pubmed-8063899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-80638992021-04-27 The complexity of tumour angiogenesis based on recently described molecules Wiśniewska, Weronika Kopka, Michał Siemiątkowska, Karolina Fudalej, Marta Magdalena Sobiborowicz, Aleksandra Badowska-Kozakiewicz, Anna Maria Contemp Oncol (Pozn) Review Paper Tumour angiogenesis is a crucial factor associated with tumour growth, progression, and metastasis. The whole process is the result of an interaction between a wide range of different molecules, influencing each other. Herein we summarize novel discoveries related to the less known angiogenic molecules such as galectins, pentraxin-3, Ral-interacting protein of 76 kDa (RLIP76), long non-coding RNAs (lncRNAs), B7-H3, and delta-like ligand-4 (DLL-4) and their role in the process of tumour angiogenesis. These molecules influence the most important molecular pathways involved in the formation of blood vessels in cancer, including the vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor interaction (VEGFR), HIF1-a activation, or PI3K/Akt/mTOR and JAK-STAT signalling pathways. Increased expression of galectins, RLIP76, and B7H3 has been proven in several malignancies. Pentraxin-3, which appears to inhibit tumour angiogenesis, shows reduced expression in tumour tissues. Anti-angiogenic treatment based mainly on VEGF inhibition has proved to be of limited effectiveness, leading to the development of drug resistance. The newly discovered molecules are of great interest as a potential source of new anti-cancer therapies. Their role as targets for new drugs and as prognostic markers in neoplasms is discussed in this review. Termedia Publishing House 2021-04-15 2021 /pmc/articles/PMC8063899/ /pubmed/33911980 http://dx.doi.org/10.5114/wo.2021.105075 Text en Copyright © 2021 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Review Paper Wiśniewska, Weronika Kopka, Michał Siemiątkowska, Karolina Fudalej, Marta Magdalena Sobiborowicz, Aleksandra Badowska-Kozakiewicz, Anna Maria The complexity of tumour angiogenesis based on recently described molecules |
title | The complexity of tumour angiogenesis based on recently described molecules |
title_full | The complexity of tumour angiogenesis based on recently described molecules |
title_fullStr | The complexity of tumour angiogenesis based on recently described molecules |
title_full_unstemmed | The complexity of tumour angiogenesis based on recently described molecules |
title_short | The complexity of tumour angiogenesis based on recently described molecules |
title_sort | complexity of tumour angiogenesis based on recently described molecules |
topic | Review Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063899/ https://www.ncbi.nlm.nih.gov/pubmed/33911980 http://dx.doi.org/10.5114/wo.2021.105075 |
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