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Clinical Characteristics and Outcomes in 314 Japanese Patients with Bacterial Endophthalmitis: A Multicenter Cohort Study from J-CREST

Bacterial endophthalmitis is an intraocular infection that causes rapid vison loss. Pathogens can infect the intraocular space directly (exogenous endophthalmitis (ExE)) or indirectly (endogenous endophthalmitis (EnE)). To identify predictive factors for the visual prognosis of Japanese patients wit...

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Autores principales: Ishikawa, Hiroto, Uchida, Kazutaka, Takesue, Yoshio, Mori, Junya, Kinoshita, Takamasa, Morikawa, Shohei, Okamoto, Fumiki, Sawada, Tomoko, Ohji, Masahito, Kanda, Takayuki, Takeuchi, Masaru, Miki, Akiko, Kusuhara, Sentaro, Ueda, Tetsuo, Ogata, Nahoko, Sugimoto, Masahiko, Kondo, Mineo, Yoshida, Shigeo, Ogata, Tadahiko, Kimura, Kazuhiro, Mitamura, Yoshinori, Jujo, Tatsuya, Takagi, Hitoshi, Terasaki, Hiroto, Sakamoto, Taiji, Sugisawa, Takaaki, Komuku, Yuki, Gomi, Fumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063932/
https://www.ncbi.nlm.nih.gov/pubmed/33805010
http://dx.doi.org/10.3390/pathogens10040390
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author Ishikawa, Hiroto
Uchida, Kazutaka
Takesue, Yoshio
Mori, Junya
Kinoshita, Takamasa
Morikawa, Shohei
Okamoto, Fumiki
Sawada, Tomoko
Ohji, Masahito
Kanda, Takayuki
Takeuchi, Masaru
Miki, Akiko
Kusuhara, Sentaro
Ueda, Tetsuo
Ogata, Nahoko
Sugimoto, Masahiko
Kondo, Mineo
Yoshida, Shigeo
Ogata, Tadahiko
Kimura, Kazuhiro
Mitamura, Yoshinori
Jujo, Tatsuya
Takagi, Hitoshi
Terasaki, Hiroto
Sakamoto, Taiji
Sugisawa, Takaaki
Komuku, Yuki
Gomi, Fumi
author_facet Ishikawa, Hiroto
Uchida, Kazutaka
Takesue, Yoshio
Mori, Junya
Kinoshita, Takamasa
Morikawa, Shohei
Okamoto, Fumiki
Sawada, Tomoko
Ohji, Masahito
Kanda, Takayuki
Takeuchi, Masaru
Miki, Akiko
Kusuhara, Sentaro
Ueda, Tetsuo
Ogata, Nahoko
Sugimoto, Masahiko
Kondo, Mineo
Yoshida, Shigeo
Ogata, Tadahiko
Kimura, Kazuhiro
Mitamura, Yoshinori
Jujo, Tatsuya
Takagi, Hitoshi
Terasaki, Hiroto
Sakamoto, Taiji
Sugisawa, Takaaki
Komuku, Yuki
Gomi, Fumi
author_sort Ishikawa, Hiroto
collection PubMed
description Bacterial endophthalmitis is an intraocular infection that causes rapid vison loss. Pathogens can infect the intraocular space directly (exogenous endophthalmitis (ExE)) or indirectly (endogenous endophthalmitis (EnE)). To identify predictive factors for the visual prognosis of Japanese patients with bacterial endophthalmitis, we retrospectively examined the bacterial endophthalmitis characteristics of 314 Japanese patients and performed statistics using these clinical data. Older patients, with significantly more severe clinical symptoms, were prevalent in the ExE group compared with the EnE group. However, the final best-corrected visual acuity (BCVA) was not significantly different between the ExE and EnE groups. Bacteria isolated from patients were not associated with age, sex, or presence of eye symptoms. Genus Streptococcus, Streptococcus pneumoniae, and Enterococcus were more prevalent in ExE patients than EnE patients and contributed to poor final BCVA. The presence of eye pain, bacterial identification, and poor BCVA at baseline were risk factors for final visual impairment.
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spelling pubmed-80639322021-04-24 Clinical Characteristics and Outcomes in 314 Japanese Patients with Bacterial Endophthalmitis: A Multicenter Cohort Study from J-CREST Ishikawa, Hiroto Uchida, Kazutaka Takesue, Yoshio Mori, Junya Kinoshita, Takamasa Morikawa, Shohei Okamoto, Fumiki Sawada, Tomoko Ohji, Masahito Kanda, Takayuki Takeuchi, Masaru Miki, Akiko Kusuhara, Sentaro Ueda, Tetsuo Ogata, Nahoko Sugimoto, Masahiko Kondo, Mineo Yoshida, Shigeo Ogata, Tadahiko Kimura, Kazuhiro Mitamura, Yoshinori Jujo, Tatsuya Takagi, Hitoshi Terasaki, Hiroto Sakamoto, Taiji Sugisawa, Takaaki Komuku, Yuki Gomi, Fumi Pathogens Article Bacterial endophthalmitis is an intraocular infection that causes rapid vison loss. Pathogens can infect the intraocular space directly (exogenous endophthalmitis (ExE)) or indirectly (endogenous endophthalmitis (EnE)). To identify predictive factors for the visual prognosis of Japanese patients with bacterial endophthalmitis, we retrospectively examined the bacterial endophthalmitis characteristics of 314 Japanese patients and performed statistics using these clinical data. Older patients, with significantly more severe clinical symptoms, were prevalent in the ExE group compared with the EnE group. However, the final best-corrected visual acuity (BCVA) was not significantly different between the ExE and EnE groups. Bacteria isolated from patients were not associated with age, sex, or presence of eye symptoms. Genus Streptococcus, Streptococcus pneumoniae, and Enterococcus were more prevalent in ExE patients than EnE patients and contributed to poor final BCVA. The presence of eye pain, bacterial identification, and poor BCVA at baseline were risk factors for final visual impairment. MDPI 2021-03-24 /pmc/articles/PMC8063932/ /pubmed/33805010 http://dx.doi.org/10.3390/pathogens10040390 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Ishikawa, Hiroto
Uchida, Kazutaka
Takesue, Yoshio
Mori, Junya
Kinoshita, Takamasa
Morikawa, Shohei
Okamoto, Fumiki
Sawada, Tomoko
Ohji, Masahito
Kanda, Takayuki
Takeuchi, Masaru
Miki, Akiko
Kusuhara, Sentaro
Ueda, Tetsuo
Ogata, Nahoko
Sugimoto, Masahiko
Kondo, Mineo
Yoshida, Shigeo
Ogata, Tadahiko
Kimura, Kazuhiro
Mitamura, Yoshinori
Jujo, Tatsuya
Takagi, Hitoshi
Terasaki, Hiroto
Sakamoto, Taiji
Sugisawa, Takaaki
Komuku, Yuki
Gomi, Fumi
Clinical Characteristics and Outcomes in 314 Japanese Patients with Bacterial Endophthalmitis: A Multicenter Cohort Study from J-CREST
title Clinical Characteristics and Outcomes in 314 Japanese Patients with Bacterial Endophthalmitis: A Multicenter Cohort Study from J-CREST
title_full Clinical Characteristics and Outcomes in 314 Japanese Patients with Bacterial Endophthalmitis: A Multicenter Cohort Study from J-CREST
title_fullStr Clinical Characteristics and Outcomes in 314 Japanese Patients with Bacterial Endophthalmitis: A Multicenter Cohort Study from J-CREST
title_full_unstemmed Clinical Characteristics and Outcomes in 314 Japanese Patients with Bacterial Endophthalmitis: A Multicenter Cohort Study from J-CREST
title_short Clinical Characteristics and Outcomes in 314 Japanese Patients with Bacterial Endophthalmitis: A Multicenter Cohort Study from J-CREST
title_sort clinical characteristics and outcomes in 314 japanese patients with bacterial endophthalmitis: a multicenter cohort study from j-crest
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063932/
https://www.ncbi.nlm.nih.gov/pubmed/33805010
http://dx.doi.org/10.3390/pathogens10040390
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