Roles of Nitrocompounds in Inhibition of Foodborne Bacteria, Parasites, and Methane Production in Economic Animals

SIMPLE SUMMARY: Supplementation of nitrocompounds in animal diets has been studied to investigate their effects on economic animals. It has been known that nitrocompounds are capable of inhibiting pathogens, parasites, methane and ammonia production. The toxicity, metabolism, and mechanisms of actions have been discussed in the review to conclude the advantages and disadvantages of application of nitrocompounds in animal production. ABSTRACT: Nitrocompounds are derivatives of hydrocarbons, alcohols, fatty acids, and esters, consisting one or more nitro functional groups. Either natural sources of nitrocompounds or synthetic chemicals have been applied in animal diets to investigate their effects on economic animals, since conjugates of 3-nitropropanol and 3-nitropropionic acid were isolated from Astragalus oblongifolius. In this review, emphasis will be placed on nitrocompounds’ antimicrobial activity, toxicity, metabolisms and mechanisms of actions. Nitrocompounds can be metabolized by ruminal microbials, such as Denitrobacterium detoxificans, or alcohol dehydrogenase in the liver. Moreover, it has been found that nitrocompounds are capable of inhibiting pathogens, parasites, methane and ammonia production; however, overdose of nitrocompounds could cause methemoglobinemia or interfere with energy production in mitochondria by inhibiting succinate dehydrogenase.