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Whole-life body composition trajectory and longevity: role of insulin

The present study assessed the body composition trajectory of rats (N = 96) placed into 5 groups according to lifespan, using dual-energy x-ray absorptiometry every 6 months until end-of-life. A striking linearity between lifespan and bone mass percentage (not absolute bone mass) was observed. Long-...

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Autores principales: Lin, Yu-Hsuan, Tsai, Shiow-Chwen, Chuang, Sheng-Ju, Harris, M. Brennan, Masodsai, Kunanya, Chen, Pei-Ni, Hsieh, Chao-Chieh, Killian, Theodore, Huang, Chih-Yang, Kuo, Chia-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064149/
https://www.ncbi.nlm.nih.gov/pubmed/33744845
http://dx.doi.org/10.18632/aging.202727
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author Lin, Yu-Hsuan
Tsai, Shiow-Chwen
Chuang, Sheng-Ju
Harris, M. Brennan
Masodsai, Kunanya
Chen, Pei-Ni
Hsieh, Chao-Chieh
Killian, Theodore
Huang, Chih-Yang
Kuo, Chia-Hua
author_facet Lin, Yu-Hsuan
Tsai, Shiow-Chwen
Chuang, Sheng-Ju
Harris, M. Brennan
Masodsai, Kunanya
Chen, Pei-Ni
Hsieh, Chao-Chieh
Killian, Theodore
Huang, Chih-Yang
Kuo, Chia-Hua
author_sort Lin, Yu-Hsuan
collection PubMed
description The present study assessed the body composition trajectory of rats (N = 96) placed into 5 groups according to lifespan, using dual-energy x-ray absorptiometry every 6 months until end-of-life. A striking linearity between lifespan and bone mass percentage (not absolute bone mass) was observed. Long-lived rats show a higher bone mass percentage with a delayed insulin rise to a similar peak level as short-lived counterparts, followed by insulin declines and bone mass loss. Decreasing insulin after streptozotocin (STZ) injection caused a rapid bone mass loss (-10.5%) with a decreased 5-day survival rate to 35% in old rats (20 months). Insulin replacement to STZ-injected rats completely blocked bone mass loss and increased the survival rate to 71%. Normal old rats (20 months) had faster lean mass loss despite greater myofiber regeneration (centronucleation) compared with the young rats (4 months). Increased CD68(+) and CD163(+) cell infiltration into insulin-depleted muscle suggests a bone marrow cell exhaustion by aging muscle. Bone produces stem cells and phagocytes to continuously rejuvenate peripheral tissues. Our data suggests that aging and unsustainable life is associated with development of disproportionality between bone and the growing body size, partly due to insulin reversal from hyperinsulinemia during late life.
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spelling pubmed-80641492021-04-26 Whole-life body composition trajectory and longevity: role of insulin Lin, Yu-Hsuan Tsai, Shiow-Chwen Chuang, Sheng-Ju Harris, M. Brennan Masodsai, Kunanya Chen, Pei-Ni Hsieh, Chao-Chieh Killian, Theodore Huang, Chih-Yang Kuo, Chia-Hua Aging (Albany NY) Research Paper The present study assessed the body composition trajectory of rats (N = 96) placed into 5 groups according to lifespan, using dual-energy x-ray absorptiometry every 6 months until end-of-life. A striking linearity between lifespan and bone mass percentage (not absolute bone mass) was observed. Long-lived rats show a higher bone mass percentage with a delayed insulin rise to a similar peak level as short-lived counterparts, followed by insulin declines and bone mass loss. Decreasing insulin after streptozotocin (STZ) injection caused a rapid bone mass loss (-10.5%) with a decreased 5-day survival rate to 35% in old rats (20 months). Insulin replacement to STZ-injected rats completely blocked bone mass loss and increased the survival rate to 71%. Normal old rats (20 months) had faster lean mass loss despite greater myofiber regeneration (centronucleation) compared with the young rats (4 months). Increased CD68(+) and CD163(+) cell infiltration into insulin-depleted muscle suggests a bone marrow cell exhaustion by aging muscle. Bone produces stem cells and phagocytes to continuously rejuvenate peripheral tissues. Our data suggests that aging and unsustainable life is associated with development of disproportionality between bone and the growing body size, partly due to insulin reversal from hyperinsulinemia during late life. Impact Journals 2021-03-19 /pmc/articles/PMC8064149/ /pubmed/33744845 http://dx.doi.org/10.18632/aging.202727 Text en Copyright: © 2021 Lin et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Lin, Yu-Hsuan
Tsai, Shiow-Chwen
Chuang, Sheng-Ju
Harris, M. Brennan
Masodsai, Kunanya
Chen, Pei-Ni
Hsieh, Chao-Chieh
Killian, Theodore
Huang, Chih-Yang
Kuo, Chia-Hua
Whole-life body composition trajectory and longevity: role of insulin
title Whole-life body composition trajectory and longevity: role of insulin
title_full Whole-life body composition trajectory and longevity: role of insulin
title_fullStr Whole-life body composition trajectory and longevity: role of insulin
title_full_unstemmed Whole-life body composition trajectory and longevity: role of insulin
title_short Whole-life body composition trajectory and longevity: role of insulin
title_sort whole-life body composition trajectory and longevity: role of insulin
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064149/
https://www.ncbi.nlm.nih.gov/pubmed/33744845
http://dx.doi.org/10.18632/aging.202727
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