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Whole-life body composition trajectory and longevity: role of insulin
The present study assessed the body composition trajectory of rats (N = 96) placed into 5 groups according to lifespan, using dual-energy x-ray absorptiometry every 6 months until end-of-life. A striking linearity between lifespan and bone mass percentage (not absolute bone mass) was observed. Long-...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064149/ https://www.ncbi.nlm.nih.gov/pubmed/33744845 http://dx.doi.org/10.18632/aging.202727 |
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author | Lin, Yu-Hsuan Tsai, Shiow-Chwen Chuang, Sheng-Ju Harris, M. Brennan Masodsai, Kunanya Chen, Pei-Ni Hsieh, Chao-Chieh Killian, Theodore Huang, Chih-Yang Kuo, Chia-Hua |
author_facet | Lin, Yu-Hsuan Tsai, Shiow-Chwen Chuang, Sheng-Ju Harris, M. Brennan Masodsai, Kunanya Chen, Pei-Ni Hsieh, Chao-Chieh Killian, Theodore Huang, Chih-Yang Kuo, Chia-Hua |
author_sort | Lin, Yu-Hsuan |
collection | PubMed |
description | The present study assessed the body composition trajectory of rats (N = 96) placed into 5 groups according to lifespan, using dual-energy x-ray absorptiometry every 6 months until end-of-life. A striking linearity between lifespan and bone mass percentage (not absolute bone mass) was observed. Long-lived rats show a higher bone mass percentage with a delayed insulin rise to a similar peak level as short-lived counterparts, followed by insulin declines and bone mass loss. Decreasing insulin after streptozotocin (STZ) injection caused a rapid bone mass loss (-10.5%) with a decreased 5-day survival rate to 35% in old rats (20 months). Insulin replacement to STZ-injected rats completely blocked bone mass loss and increased the survival rate to 71%. Normal old rats (20 months) had faster lean mass loss despite greater myofiber regeneration (centronucleation) compared with the young rats (4 months). Increased CD68(+) and CD163(+) cell infiltration into insulin-depleted muscle suggests a bone marrow cell exhaustion by aging muscle. Bone produces stem cells and phagocytes to continuously rejuvenate peripheral tissues. Our data suggests that aging and unsustainable life is associated with development of disproportionality between bone and the growing body size, partly due to insulin reversal from hyperinsulinemia during late life. |
format | Online Article Text |
id | pubmed-8064149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-80641492021-04-26 Whole-life body composition trajectory and longevity: role of insulin Lin, Yu-Hsuan Tsai, Shiow-Chwen Chuang, Sheng-Ju Harris, M. Brennan Masodsai, Kunanya Chen, Pei-Ni Hsieh, Chao-Chieh Killian, Theodore Huang, Chih-Yang Kuo, Chia-Hua Aging (Albany NY) Research Paper The present study assessed the body composition trajectory of rats (N = 96) placed into 5 groups according to lifespan, using dual-energy x-ray absorptiometry every 6 months until end-of-life. A striking linearity between lifespan and bone mass percentage (not absolute bone mass) was observed. Long-lived rats show a higher bone mass percentage with a delayed insulin rise to a similar peak level as short-lived counterparts, followed by insulin declines and bone mass loss. Decreasing insulin after streptozotocin (STZ) injection caused a rapid bone mass loss (-10.5%) with a decreased 5-day survival rate to 35% in old rats (20 months). Insulin replacement to STZ-injected rats completely blocked bone mass loss and increased the survival rate to 71%. Normal old rats (20 months) had faster lean mass loss despite greater myofiber regeneration (centronucleation) compared with the young rats (4 months). Increased CD68(+) and CD163(+) cell infiltration into insulin-depleted muscle suggests a bone marrow cell exhaustion by aging muscle. Bone produces stem cells and phagocytes to continuously rejuvenate peripheral tissues. Our data suggests that aging and unsustainable life is associated with development of disproportionality between bone and the growing body size, partly due to insulin reversal from hyperinsulinemia during late life. Impact Journals 2021-03-19 /pmc/articles/PMC8064149/ /pubmed/33744845 http://dx.doi.org/10.18632/aging.202727 Text en Copyright: © 2021 Lin et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Lin, Yu-Hsuan Tsai, Shiow-Chwen Chuang, Sheng-Ju Harris, M. Brennan Masodsai, Kunanya Chen, Pei-Ni Hsieh, Chao-Chieh Killian, Theodore Huang, Chih-Yang Kuo, Chia-Hua Whole-life body composition trajectory and longevity: role of insulin |
title | Whole-life body composition trajectory and longevity: role of insulin |
title_full | Whole-life body composition trajectory and longevity: role of insulin |
title_fullStr | Whole-life body composition trajectory and longevity: role of insulin |
title_full_unstemmed | Whole-life body composition trajectory and longevity: role of insulin |
title_short | Whole-life body composition trajectory and longevity: role of insulin |
title_sort | whole-life body composition trajectory and longevity: role of insulin |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064149/ https://www.ncbi.nlm.nih.gov/pubmed/33744845 http://dx.doi.org/10.18632/aging.202727 |
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