Cargando…

Identification of GSPT1 as prognostic biomarker and promoter of malignant colon cancer cell phenotypes via the GSK-3β/CyclinD1 pathway

Colon cancer is the third most common malignant tumor and its mortality rate ranks fourth among all malignant tumor types. Bioinformatics analysis has shown that GSPT1 is dysregulated in colon cancer and is associated with tumor progression. However, the underlying mechanism remains unclear. To addr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Long, Xuan, Zhao, Lijun, Li, Guoqiang, Wang, Ziwei, Deng, Zhigang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064227/ https://www.ncbi.nlm.nih.gov/pubmed/33819920 http://dx.doi.org/10.18632/aging.202796

Ejemplares similares

CyclinD1, a prominent prognostic marker for endometrial diseases
por: Liang, Shuo, et al.
Publicado: (2013)

CCN1 stimulated the osteoblasts via PTEN/AKT/GSK3β/cyclinD1 signal pathway in Myeloma Bone Disease
por: Yan, Siyang, et al.
Publicado: (2019)

USP5 Sustains the Proliferation of Glioblastoma Through Stabilization of CyclinD1
por: Li, Gen, et al.
Publicado: (2021)

Role of GSPT1 and GSPT2 polymorphisms in different outcomes upon Hepatitis B virus infection and prognosis to lamivudine therapy
por: Liu, Wenxuan, et al.
Publicado: (2019)

The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3β/β-Catenin/cyclinD1 Signaling Pathway
por: Li, Shijie, et al.
Publicado: (2017)

CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization
por: Tung, Jai-Nien, et al.
Publicado: (2010)

Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation
por: Zhang, Mengxue, et al.
Publicado: (2023)

Inhibition of the CyclinD1 promoter in response to sonic hedgehog signaling pathway transduction is mediated by Gli1
por: Lin, Zhongxiao, et al.
Publicado: (2017)

Combined Use of cyclinD1 and Ki67 for Prognosis of Luminal-Like Breast Cancer Patients
por: Hao, Junmei, et al.
Publicado: (2021)

The pentapeptide Gly-Thr-Gly-Lys-Thr confers sensitivity to anti-cancer drugs by inhibition of CAGE binding to GSK3β and decreasing the expression of cyclinD1
por: Kim, Youngmi, et al.
Publicado: (2017)

Estrogen Receptor Beta (ERβ) Mediated-CyclinD1 Degradation via Autophagy Plays an Anti-Proliferation Role in Colon Cells
por: Wei, Yong, et al.
Publicado: (2019)

Cordycepin Suppresses The Malignant Phenotypes of Colon Cancer Cells through The GSK3ß/ß-catenin/cyclin D1 Signaling Pathway
por: Xu, Jie, et al.
Publicado: (2022)

CyclinD1 and p57(kip2) as biomarkers in differentiation, metastasis and prognosis of gastric cardia adenocarcinoma
por: Ru, Yi, et al.
Publicado: (2017)

Nano-curcumin’s suppression of breast cancer cells (MCF7) through the inhibition of cyclinD1 expression
por: Hosseini, Sare, et al.
Publicado: (2019)

Cul4B promotes the progression of ovarian cancer by upregulating the expression of CDK2 and CyclinD1
por: Duan, Peng-jing, et al.
Publicado: (2020)

PKC promotes proliferation of airway smooth muscle cells by regulating cyclinD1 expression in asthmatic rats
por: Qiao, Li-fen, et al.
Publicado: (2008)

SOCS1 blocks G1-S transition in hepatocellular carcinoma by reducing the stability of the CyclinD1/CDK4 complex in the nucleus
por: Ding, Jun, et al.
Publicado: (2020)

BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF‐BP1
por: Wang, Fengyun, et al.
Publicado: (2021)

Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain
por: Artegiani, Benedetta, et al.
Publicado: (2011)

CyclinD1 protein plays different roles in modulating chemoresponses in MCF7 and MDA-MB231 cells
por: Sun, Yuan, et al.
Publicado: (2012)

The Role of EGFR/PI3K/Akt/cyclinD1 Signaling Pathway in Acquired Middle Ear Cholesteatoma
por: Liu, Wei, et al.
Publicado: (2013)

CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma
por: Qi, Yongqiang, et al.
Publicado: (2019)

CyclinD1 Is a New Target Gene of Tumor Suppressor MiR-520e in Breast Cancer
por: Liang, Quan, et al.
Publicado: (2019)

MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling
por: Cao, Ling, et al.
Publicado: (2018)

Influence of cyclin D1 splicing variants expression on breast cancer chemoresistance via CDK4/CyclinD1‐pRB‐E2F1 pathway
por: Wang, Jing, et al.
Publicado: (2023)

Erratum to: BAP1 promotes viability and migration of ECA109 cells through KLF5/CyclinD1/FGF‐BP1
Publicado: (2021)

Low temperature plasma promoting fibroblast proliferation by activating the NF-κB pathway and increasing cyclinD1 expression
por: Liu, Jin-Ren, et al.
Publicado: (2017)

BHLHE41 promotes U87 and U251 cell proliferation via ERK/cyclinD1 signaling pathway
por: Wang, Chen, et al.
Publicado: (2019)

Validation of absolutely quantitated Ki67 and cyclinD1 protein levels for prognosis of Luminal‐like breast cancer patients
por: Yu, Guohua, et al.
Publicado: (2022)

Identification of critical genes to predict recurrence and death in colon cancer: integrating gene expression and bioinformatics analysis
por: Long, Xuan, et al.
Publicado: (2018)

Reduced expression of microRNA-206 regulates cell proliferation via cyclinD2 in gliomas
por: YANG, XUE, et al.
Publicado: (2015)

Aspirin regulation of c-myc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptor-positive breast cancer cells
por: Cheng, Ran, et al.
Publicado: (2017)

The different roles of cyclinD1-CDK4 in STP and mGluR-LTD during the postnatal development in mice hippocampus area CA1
por: Li, Chenchen, et al.
Publicado: (2007)

Epac1, PDE4, and PKC protein expression and their association with AKAP95, Cx43, and cyclinD2/E1 in breast cancer tissues
por: Huang, Ping, et al.
Publicado: (2017)

HP-CagA+ Regulates the Expression of CDK4/CyclinD1 via reg3 to Change Cell Cycle and Promote Cell Proliferation
por: Liu, Bin, et al.
Publicado: (2019)

Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling
por: Tang, Jing, et al.
Publicado: (2017)

Notch-1 signaling promotes the cyclinD1-dependent generation of mammary tumor-initiating cells which can revert to bi-potential progenitors from which they arise
por: Ling, Hua, et al.
Publicado: (2012)

Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells
por: Sellar, Rob S., et al.
Publicado: (2022)

Circular RNA hsa_circ_105039 promotes cardiomyocyte differentiation by sponging miR-17 to regulate cyclinD2 expression
por: Yu, Boshi, et al.
Publicado: (2021)

miR-338-3p Is Down-Regulated by Hepatitis B Virus X and Inhibits Cell Proliferation by Targeting the 3′-UTR Region of CyclinD1
por: Fu, Xiaoyu, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ssc5uvgek7s6remf1k0kjfpbav