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A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a highly heterogeneous disease. Reduced expression of focal adhesion is considered as an important prerequisite for tumor cell invasion and metastasis. However, the prognostic value of focal adhesion related genes in HCC remains to be further determined. In this stu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064231/ https://www.ncbi.nlm.nih.gov/pubmed/33850056 http://dx.doi.org/10.18632/aging.202871 |
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author | Lin, Zhuo Miao, Dan Xu, Qian Wang, Xiaodong Yu, Fujun |
author_facet | Lin, Zhuo Miao, Dan Xu, Qian Wang, Xiaodong Yu, Fujun |
author_sort | Lin, Zhuo |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) is a highly heterogeneous disease. Reduced expression of focal adhesion is considered as an important prerequisite for tumor cell invasion and metastasis. However, the prognostic value of focal adhesion related genes in HCC remains to be further determined. In this study, RNA expression profiles were downloaded from public databases. A five focal adhesion related gene signature model was established by the least absolute shrinkage and selection operator Cox regression analysis, which categorized patients into high- and low-risk groups. Multivariate Cox regression analysis showed that the risk score was an independent predictor for overall survival. Single-sample gene set enrichment analysis revealed that immune status was different between the two risk groups, and tumor-related pathways were enriched in high-risk group. The risk score was significantly associated with tumor grade, tumor stage, immune scores, and immune infiltrate types. Pearson correlation showed that the expression level of prognostic genes was associated with anti-tumor drug sensitivity. Besides, the mRNA and protein expression of prognostic genes was significantly different between HCC tissues and adjacent non-tumorous tissues in our separate cohort. Taken together, a novel focal adhesion related gene signature can be used for prognostic prediction in HCC, which may be a therapeutic alternative. |
format | Online Article Text |
id | pubmed-8064231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-80642312021-04-26 A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma Lin, Zhuo Miao, Dan Xu, Qian Wang, Xiaodong Yu, Fujun Aging (Albany NY) Research Paper Hepatocellular carcinoma (HCC) is a highly heterogeneous disease. Reduced expression of focal adhesion is considered as an important prerequisite for tumor cell invasion and metastasis. However, the prognostic value of focal adhesion related genes in HCC remains to be further determined. In this study, RNA expression profiles were downloaded from public databases. A five focal adhesion related gene signature model was established by the least absolute shrinkage and selection operator Cox regression analysis, which categorized patients into high- and low-risk groups. Multivariate Cox regression analysis showed that the risk score was an independent predictor for overall survival. Single-sample gene set enrichment analysis revealed that immune status was different between the two risk groups, and tumor-related pathways were enriched in high-risk group. The risk score was significantly associated with tumor grade, tumor stage, immune scores, and immune infiltrate types. Pearson correlation showed that the expression level of prognostic genes was associated with anti-tumor drug sensitivity. Besides, the mRNA and protein expression of prognostic genes was significantly different between HCC tissues and adjacent non-tumorous tissues in our separate cohort. Taken together, a novel focal adhesion related gene signature can be used for prognostic prediction in HCC, which may be a therapeutic alternative. Impact Journals 2021-04-13 /pmc/articles/PMC8064231/ /pubmed/33850056 http://dx.doi.org/10.18632/aging.202871 Text en Copyright: © 2021 Lin et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Lin, Zhuo Miao, Dan Xu, Qian Wang, Xiaodong Yu, Fujun A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma |
title | A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma |
title_full | A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma |
title_fullStr | A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma |
title_full_unstemmed | A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma |
title_short | A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma |
title_sort | novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064231/ https://www.ncbi.nlm.nih.gov/pubmed/33850056 http://dx.doi.org/10.18632/aging.202871 |
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