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A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a highly heterogeneous disease. Reduced expression of focal adhesion is considered as an important prerequisite for tumor cell invasion and metastasis. However, the prognostic value of focal adhesion related genes in HCC remains to be further determined. In this stu...

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Autores principales: Lin, Zhuo, Miao, Dan, Xu, Qian, Wang, Xiaodong, Yu, Fujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064231/
https://www.ncbi.nlm.nih.gov/pubmed/33850056
http://dx.doi.org/10.18632/aging.202871
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author Lin, Zhuo
Miao, Dan
Xu, Qian
Wang, Xiaodong
Yu, Fujun
author_facet Lin, Zhuo
Miao, Dan
Xu, Qian
Wang, Xiaodong
Yu, Fujun
author_sort Lin, Zhuo
collection PubMed
description Hepatocellular carcinoma (HCC) is a highly heterogeneous disease. Reduced expression of focal adhesion is considered as an important prerequisite for tumor cell invasion and metastasis. However, the prognostic value of focal adhesion related genes in HCC remains to be further determined. In this study, RNA expression profiles were downloaded from public databases. A five focal adhesion related gene signature model was established by the least absolute shrinkage and selection operator Cox regression analysis, which categorized patients into high- and low-risk groups. Multivariate Cox regression analysis showed that the risk score was an independent predictor for overall survival. Single-sample gene set enrichment analysis revealed that immune status was different between the two risk groups, and tumor-related pathways were enriched in high-risk group. The risk score was significantly associated with tumor grade, tumor stage, immune scores, and immune infiltrate types. Pearson correlation showed that the expression level of prognostic genes was associated with anti-tumor drug sensitivity. Besides, the mRNA and protein expression of prognostic genes was significantly different between HCC tissues and adjacent non-tumorous tissues in our separate cohort. Taken together, a novel focal adhesion related gene signature can be used for prognostic prediction in HCC, which may be a therapeutic alternative.
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spelling pubmed-80642312021-04-26 A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma Lin, Zhuo Miao, Dan Xu, Qian Wang, Xiaodong Yu, Fujun Aging (Albany NY) Research Paper Hepatocellular carcinoma (HCC) is a highly heterogeneous disease. Reduced expression of focal adhesion is considered as an important prerequisite for tumor cell invasion and metastasis. However, the prognostic value of focal adhesion related genes in HCC remains to be further determined. In this study, RNA expression profiles were downloaded from public databases. A five focal adhesion related gene signature model was established by the least absolute shrinkage and selection operator Cox regression analysis, which categorized patients into high- and low-risk groups. Multivariate Cox regression analysis showed that the risk score was an independent predictor for overall survival. Single-sample gene set enrichment analysis revealed that immune status was different between the two risk groups, and tumor-related pathways were enriched in high-risk group. The risk score was significantly associated with tumor grade, tumor stage, immune scores, and immune infiltrate types. Pearson correlation showed that the expression level of prognostic genes was associated with anti-tumor drug sensitivity. Besides, the mRNA and protein expression of prognostic genes was significantly different between HCC tissues and adjacent non-tumorous tissues in our separate cohort. Taken together, a novel focal adhesion related gene signature can be used for prognostic prediction in HCC, which may be a therapeutic alternative. Impact Journals 2021-04-13 /pmc/articles/PMC8064231/ /pubmed/33850056 http://dx.doi.org/10.18632/aging.202871 Text en Copyright: © 2021 Lin et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Lin, Zhuo
Miao, Dan
Xu, Qian
Wang, Xiaodong
Yu, Fujun
A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma
title A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma
title_full A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma
title_fullStr A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma
title_full_unstemmed A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma
title_short A novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma
title_sort novel focal adhesion related gene signature for prognostic prediction in hepatocellular carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064231/
https://www.ncbi.nlm.nih.gov/pubmed/33850056
http://dx.doi.org/10.18632/aging.202871
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