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Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase

AIMS: Atherosclerotic vascular disease has an inflammatory pathogenesis. Heme from intraplaque haemorrhage may drive a protective and pro-resolving macrophage M2-like phenotype, Mhem, via AMPK and activating transcription factor 1 (ATF1). The antidiabetic drug metformin may also activate AMPK-depend...

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Detalles Bibliográficos
Autores principales:	Seneviratne, Anusha, Cave, Luke, Hyde, Gareth, Moestrup, Soren Kragh, Carling, David, Mason, Justin C, Haskard, Dorian O, Boyle, Joseph James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064441/ https://www.ncbi.nlm.nih.gov/pubmed/32667970 http://dx.doi.org/10.1093/cvr/cvaa171

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