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Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases
With a size range from 30 to 1000 nm, extracellular vesicles (EVs) are one of the smallest cell components able to transport biologically active molecules. They mediate intercellular communications and play a fundamental role in the maintenance of tissue homeostasis and pathogenesis in several types...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064535/ https://www.ncbi.nlm.nih.gov/pubmed/33813952 http://dx.doi.org/10.1177/0300985821999328 |
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author | Bongiovanni, Laura Andriessen, Anneloes Wauben, Marca H. M. Hoen, Esther N. M. Nolte-’t de Bruin, Alain |
author_facet | Bongiovanni, Laura Andriessen, Anneloes Wauben, Marca H. M. Hoen, Esther N. M. Nolte-’t de Bruin, Alain |
author_sort | Bongiovanni, Laura |
collection | PubMed |
description | With a size range from 30 to 1000 nm, extracellular vesicles (EVs) are one of the smallest cell components able to transport biologically active molecules. They mediate intercellular communications and play a fundamental role in the maintenance of tissue homeostasis and pathogenesis in several types of diseases. In particular, EVs actively contribute to cancer initiation and progression, and there is emerging understanding of their role in creation of the metastatic niche. This fact underlies the recent exponential growth in EV research, which has improved our understanding of their specific roles in disease and their potential applications in diagnosis and therapy. EVs and their biomolecular cargo reflect the state of the diseased donor cells, and can be detected in body fluids and exploited as biomarkers in cancer and other diseases. Relatively few studies have been published on EVs in the veterinary field. This review provides an overview of the features and biology of EVs as well as recent developments in EV research including techniques for isolation and analysis, and will address the way in which the EVs released by diseased tissues can be studied and exploited in the field of veterinary pathology. Uniquely, this review emphasizes the important contribution that pathologists can make to the field of EV research: pathologists can help EV scientists in studying and confirming the role of EVs and their molecular cargo in diseased tissues and as biomarkers in liquid biopsies. |
format | Online Article Text |
id | pubmed-8064535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-80645352021-05-13 Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases Bongiovanni, Laura Andriessen, Anneloes Wauben, Marca H. M. Hoen, Esther N. M. Nolte-’t de Bruin, Alain Vet Pathol Reviews With a size range from 30 to 1000 nm, extracellular vesicles (EVs) are one of the smallest cell components able to transport biologically active molecules. They mediate intercellular communications and play a fundamental role in the maintenance of tissue homeostasis and pathogenesis in several types of diseases. In particular, EVs actively contribute to cancer initiation and progression, and there is emerging understanding of their role in creation of the metastatic niche. This fact underlies the recent exponential growth in EV research, which has improved our understanding of their specific roles in disease and their potential applications in diagnosis and therapy. EVs and their biomolecular cargo reflect the state of the diseased donor cells, and can be detected in body fluids and exploited as biomarkers in cancer and other diseases. Relatively few studies have been published on EVs in the veterinary field. This review provides an overview of the features and biology of EVs as well as recent developments in EV research including techniques for isolation and analysis, and will address the way in which the EVs released by diseased tissues can be studied and exploited in the field of veterinary pathology. Uniquely, this review emphasizes the important contribution that pathologists can make to the field of EV research: pathologists can help EV scientists in studying and confirming the role of EVs and their molecular cargo in diseased tissues and as biomarkers in liquid biopsies. SAGE Publications 2021-04-05 2021-05 /pmc/articles/PMC8064535/ /pubmed/33813952 http://dx.doi.org/10.1177/0300985821999328 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Reviews Bongiovanni, Laura Andriessen, Anneloes Wauben, Marca H. M. Hoen, Esther N. M. Nolte-’t de Bruin, Alain Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases |
title | Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases |
title_full | Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases |
title_fullStr | Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases |
title_full_unstemmed | Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases |
title_short | Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases |
title_sort | extracellular vesicles: novel opportunities to understand and detect neoplastic diseases |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064535/ https://www.ncbi.nlm.nih.gov/pubmed/33813952 http://dx.doi.org/10.1177/0300985821999328 |
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