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New monoclonal antibodies that recognize an unglycosylated, conserved, extracellular region of CD44 in vitro and in vivo, and can block tumorigenesis

CD44 is a transmembrane glycoprotein that binds to hyaluronic acid, plays roles in a number of cellular processes and is expressed in a variety of cell types. It is up-regulated in stem cells and cancer. Anti-CD44 monoclonal antibodies affect cell motility and aggregation, and repress tumorigenesis...

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Detalles Bibliográficos
Autores principales:	Lusche, Daniel F., Wessels, Deborah J., Reis, Ryan J., Forrest, Cristopher C., Thumann, Alexis R., Soll, David R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064539/ https://www.ncbi.nlm.nih.gov/pubmed/33891595 http://dx.doi.org/10.1371/journal.pone.0250175

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