Observing spontaneous, accelerated substrate binding in molecular dynamics simulations of glutamate transporters

Glutamate transporters are essential for removing the neurotransmitter glutamate from the synaptic cleft. Glutamate transport across the membrane is associated with elevator-like structural changes of the transport domain. These structural changes require initial binding of the organic substrate to...

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Detalles Bibliográficos
Autores principales: Wang, Jiali, Li, Peifan, Yu, Xiaozhen, Grewer, Christof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064580/
https://www.ncbi.nlm.nih.gov/pubmed/33891665
http://dx.doi.org/10.1371/journal.pone.0250635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064580/
https://www.ncbi.nlm.nih.gov/pubmed/33891665
http://dx.doi.org/10.1371/journal.pone.0250635

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