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Observing spontaneous, accelerated substrate binding in molecular dynamics simulations of glutamate transporters
Glutamate transporters are essential for removing the neurotransmitter glutamate from the synaptic cleft. Glutamate transport across the membrane is associated with elevator-like structural changes of the transport domain. These structural changes require initial binding of the organic substrate to...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064580/ https://www.ncbi.nlm.nih.gov/pubmed/33891665 http://dx.doi.org/10.1371/journal.pone.0250635 |