Immunoglobulin G4-Related Disease Masquerading an Epidural Spinal Cord Tumor

Background  Immunoglobulin G4–related disease (IgG4-RD) is a recently identified multisystemic fibroinflammatory condition of unclear etiology. IgG4-RD of the epidural tissue causing spinal cord compression is extremely rare. Case description  Here, we present a 27-year-old male with epidural mass,...

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Autores principales: Abdulla, Ebtesam, Luther, Harleen, Shah, Tejal, Chandran, Nisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064830/
https://www.ncbi.nlm.nih.gov/pubmed/33927535
http://dx.doi.org/10.1055/s-0041-1722841
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author Abdulla, Ebtesam
Luther, Harleen
Shah, Tejal
Chandran, Nisha
author_facet Abdulla, Ebtesam
Luther, Harleen
Shah, Tejal
Chandran, Nisha
author_sort Abdulla, Ebtesam
collection PubMed
description Background  Immunoglobulin G4–related disease (IgG4-RD) is a recently identified multisystemic fibroinflammatory condition of unclear etiology. IgG4-RD of the epidural tissue causing spinal cord compression is extremely rare. Case description  Here, we present a 27-year-old male with epidural mass, causing spinal cord compression at the level of D5-D6. The mass proved pathologically to be epidural inflammatory pseudotumor (IPT) related to IgG4. Spinal decompression was done. The patient was started on steroid treatment and reported a complete resolution of his symptoms over a 3 years’ follow-up period. Conclusion  To the authors’ knowledge, this is the first case of IgG4-related epidural IPT and spinal cord compression in Bahrain and the Middle East. IgG4-RD should always be considered as a part of the differential diagnosis of spinal tumors.
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spelling pubmed-80648302021-04-28 Immunoglobulin G4-Related Disease Masquerading an Epidural Spinal Cord Tumor Abdulla, Ebtesam Luther, Harleen Shah, Tejal Chandran, Nisha J Neurosci Rural Pract Background  Immunoglobulin G4–related disease (IgG4-RD) is a recently identified multisystemic fibroinflammatory condition of unclear etiology. IgG4-RD of the epidural tissue causing spinal cord compression is extremely rare. Case description  Here, we present a 27-year-old male with epidural mass, causing spinal cord compression at the level of D5-D6. The mass proved pathologically to be epidural inflammatory pseudotumor (IPT) related to IgG4. Spinal decompression was done. The patient was started on steroid treatment and reported a complete resolution of his symptoms over a 3 years’ follow-up period. Conclusion  To the authors’ knowledge, this is the first case of IgG4-related epidural IPT and spinal cord compression in Bahrain and the Middle East. IgG4-RD should always be considered as a part of the differential diagnosis of spinal tumors. Thieme Medical and Scientific Publishers Pvt. Ltd. 2021-04 2021-03-15 /pmc/articles/PMC8064830/ /pubmed/33927535 http://dx.doi.org/10.1055/s-0041-1722841 Text en Association for Helping Neurosurgical Sick People. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Abdulla, Ebtesam
Luther, Harleen
Shah, Tejal
Chandran, Nisha
Immunoglobulin G4-Related Disease Masquerading an Epidural Spinal Cord Tumor
title Immunoglobulin G4-Related Disease Masquerading an Epidural Spinal Cord Tumor
title_full Immunoglobulin G4-Related Disease Masquerading an Epidural Spinal Cord Tumor
title_fullStr Immunoglobulin G4-Related Disease Masquerading an Epidural Spinal Cord Tumor
title_full_unstemmed Immunoglobulin G4-Related Disease Masquerading an Epidural Spinal Cord Tumor
title_short Immunoglobulin G4-Related Disease Masquerading an Epidural Spinal Cord Tumor
title_sort immunoglobulin g4-related disease masquerading an epidural spinal cord tumor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064830/
https://www.ncbi.nlm.nih.gov/pubmed/33927535
http://dx.doi.org/10.1055/s-0041-1722841
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AT shahtejal immunoglobuling4relateddiseasemasqueradinganepiduralspinalcordtumor
AT chandrannisha immunoglobuling4relateddiseasemasqueradinganepiduralspinalcordtumor

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