Cytocompatibility of Ti–xZr alloys as dental implant materials

Ti–xZr (x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti–xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogenic...

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Detalles Bibliográficos
Autores principales: Ou, Pinghua, Hao, Cong, Liu, Jue, He, Rengui, Wang, Baoqi, Ruan, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Biocompatibility Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064977/
https://www.ncbi.nlm.nih.gov/pubmed/33891193
http://dx.doi.org/10.1007/s10856-021-06522-w
Descripción
Sumario:Ti–xZr (x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti–xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogenic induction using CCK-8 and live/dead cell assays, electron microscopy, and real-time PCR. The Ti–xZr alloys were non-toxic and showed superior biomechanics compared to commercially pure titanium (cpTi). Ti–45Zr had the optimum strength/elastic modulus ratio and osteogenic activity, thus is a promising to used as dental implants.

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