Cytocompatibility of Ti–xZr alloys as dental implant materials

Ti–xZr (x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti–xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogenic...

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Autores principales: Ou, Pinghua, Hao, Cong, Liu, Jue, He, Rengui, Wang, Baoqi, Ruan, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Biocompatibility Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064977/
https://www.ncbi.nlm.nih.gov/pubmed/33891193
http://dx.doi.org/10.1007/s10856-021-06522-w
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author Ou, Pinghua
Hao, Cong
Liu, Jue
He, Rengui
Wang, Baoqi
Ruan, Jianming
author_facet Ou, Pinghua
Hao, Cong
Liu, Jue
He, Rengui
Wang, Baoqi
Ruan, Jianming
author_sort Ou, Pinghua
collection PubMed
description Ti–xZr (x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti–xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogenic induction using CCK-8 and live/dead cell assays, electron microscopy, and real-time PCR. The Ti–xZr alloys were non-toxic and showed superior biomechanics compared to commercially pure titanium (cpTi). Ti–45Zr had the optimum strength/elastic modulus ratio and osteogenic activity, thus is a promising to used as dental implants.
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spelling pubmed-80649772021-05-05 Cytocompatibility of Ti–xZr alloys as dental implant materials Ou, Pinghua Hao, Cong Liu, Jue He, Rengui Wang, Baoqi Ruan, Jianming J Mater Sci Mater Med Biocompatibility Studies Ti–xZr (x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti–xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogenic induction using CCK-8 and live/dead cell assays, electron microscopy, and real-time PCR. The Ti–xZr alloys were non-toxic and showed superior biomechanics compared to commercially pure titanium (cpTi). Ti–45Zr had the optimum strength/elastic modulus ratio and osteogenic activity, thus is a promising to used as dental implants. Springer US 2021-04-23 2021 /pmc/articles/PMC8064977/ /pubmed/33891193 http://dx.doi.org/10.1007/s10856-021-06522-w Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biocompatibility Studies
Ou, Pinghua
Hao, Cong
Liu, Jue
He, Rengui
Wang, Baoqi
Ruan, Jianming
Cytocompatibility of Ti–xZr alloys as dental implant materials
title Cytocompatibility of Ti–xZr alloys as dental implant materials
title_full Cytocompatibility of Ti–xZr alloys as dental implant materials
title_fullStr Cytocompatibility of Ti–xZr alloys as dental implant materials
title_full_unstemmed Cytocompatibility of Ti–xZr alloys as dental implant materials
title_short Cytocompatibility of Ti–xZr alloys as dental implant materials
title_sort cytocompatibility of ti–xzr alloys as dental implant materials
topic Biocompatibility Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8064977/
https://www.ncbi.nlm.nih.gov/pubmed/33891193
http://dx.doi.org/10.1007/s10856-021-06522-w
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