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Combined inhibition of PD-1/PD-L1, Lag-3, and Tim-3 axes augments antitumor immunity in gastric cancer–T cell coculture models

BACKGROUND: Immunotherapy targeting PD-1 provides a limited survival benefit in patients with unresectable advanced or recurrent gastric cancer (GC). Beside PD-L1, the expression of inhibitory ligands such as CEACAM-1 and LSECtin on GC cells account for this limitation. Here we assessed their expres...

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Detalles Bibliográficos
Autores principales:	Mimura, Kosaku, Kua, Ley-Fang, Xiao, Jin-Fen, Asuncion, Bernadette Reyna, Nakayama, Yuko, Syn, Nicholas, Fazreen, Zul, Soong, Richie, Kono, Koji, Yong, Wei-Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065004/ https://www.ncbi.nlm.nih.gov/pubmed/33611641 http://dx.doi.org/10.1007/s10120-020-01151-8

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