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Transition state analogue of MTAP extends lifespan of APC(Min/+) mice

A mouse model of human Familial Adenomatous Polyposis responds favorably to pharmacological inhibition of 5′-methylthioadenosine phosphorylase (MTAP). Methylthio-DADMe-Immucillin-A (MTDIA) is an orally available, transition state analogue inhibitor of MTAP. 5′-Methylthioadenosine (MTA), the substrat...

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Detalles Bibliográficos
Autores principales:	Firestone, Ross S., Feng, Mu, Basu, Indranil, Peregrina, Karina, Augenlicht, Leonard H., Schramm, Vern L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065027/ https://www.ncbi.nlm.nih.gov/pubmed/33893330 http://dx.doi.org/10.1038/s41598-021-87734-6

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