Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development

Inherited mutations in BRCA1, BRCA2, and PALB2 cause a high risk of breast cancer. Here, we conducted parallel conditional knockout (CKO) of Brca1, Palb2, and Brca2, individually and in combination, along with one copy of Trp53, in the mammary gland of nulliparous female mice. We observed a function...

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Detalles Bibliográficos
Autores principales: Huo, Yanying, Selenica, Pier, Mahdi, Amar H., Pareja, Fresia, Kyker-Snowman, Kelly, Chen, Ying, Kumar, Rahul, Da Cruz Paula, Arnaud, Basili, Thais, Brown, David N., Pei, Xin, Riaz, Nadeem, Tan, Yongmei, Huang, Yu-Xiu, Li, Tao, Barnard, Nicola J., Reis-Filho, Jorge S., Weigelt, Britta, Xia, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065161/
https://www.ncbi.nlm.nih.gov/pubmed/33893322
http://dx.doi.org/10.1038/s41523-021-00253-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065161/
https://www.ncbi.nlm.nih.gov/pubmed/33893322
http://dx.doi.org/10.1038/s41523-021-00253-5

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