Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology

The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtyp...

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Detalles Bibliográficos
Autores principales: Baglietto-Vargas, David, Forner, Stefania, Cai, Lena, Martini, Alessandra C., Trujillo-Estrada, Laura, Swarup, Vivek, Nguyen, Marie Minh Thu, Do Huynh, Kelly, Javonillo, Dominic I., Tran, Kristine Minh, Phan, Jimmy, Jiang, Shan, Kramár, Enikö A., Nuñez-Diaz, Cristina, Balderrama-Gutierrez, Gabriela, Garcia, Franklin, Childs, Jessica, Rodriguez-Ortiz, Carlos J., Garcia-Leon, Juan Antonio, Kitazawa, Masashi, Shahnawaz, Mohammad, Matheos, Dina P., Ma, Xinyi, Da Cunha, Celia, Walls, Ken C., Ager, Rahasson R., Soto, Claudio, Gutierrez, Antonia, Moreno-Gonzalez, Ines, Mortazavi, Ali, Tenner, Andrea J., MacGregor, Grant R., Wood, Marcelo, Green, Kim N., LaFerla, Frank M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065162/
https://www.ncbi.nlm.nih.gov/pubmed/33893290
http://dx.doi.org/10.1038/s41467-021-22624-z

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