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Age and insulin-like growth factor-1 impact PCNA monoubiquitination in UVB-irradiated human skin

Nonmelanoma skin cancers occur primarily in individuals over the age of 60 and are characterized by an abundance of ultraviolet (UV) signature mutations in keratinocyte DNA. Though geriatric skin removes UV photoproducts from DNA less efficiently than young adult skin, it is not known whether the ut...

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Detalles Bibliográficos
Autores principales:	Hutcherson, Rebekah J., Gabbard, Ryan D., Castellanos, Amber J., Travers, Jeffrey B., Kemp, Michael G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065225/ https://www.ncbi.nlm.nih.gov/pubmed/33753168 http://dx.doi.org/10.1016/j.jbc.2021.100570

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