Metabolic selection of a homologous recombination-mediated gene loss protects Trypanosoma brucei from ROS production by glycosomal fumarate reductase

The genome of trypanosomatids rearranges by using repeated sequences as platforms for amplification or deletion of genomic segments. These stochastic recombination events have a direct impact on gene dosage and foster the selection of adaptive traits in response to environmental pressure. We provide...

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Detalles Bibliográficos
Autores principales: Wargnies, Marion, Plazolles, Nicolas, Schenk, Robin, Villafraz, Oriana, Dupuy, Jean-William, Biran, Marc, Bachmaier, Sabine, Baudouin, Hélène, Clayton, Christine, Boshart, Michael, Bringaud, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065229/
https://www.ncbi.nlm.nih.gov/pubmed/33741344
http://dx.doi.org/10.1016/j.jbc.2021.100548

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