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p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts

Hematopoietic stem cells (HSCs) and their progeny sustain lifetime hematopoiesis. Aging alters HSC function, number, and composition and increases risk of hematological malignancies, but how these changes occur in HSCs remains unclear. Signaling via p38 mitogen-activated kinase (p38MAPK) has been pr...

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Detalles Bibliográficos
Autores principales:	Sorimachi, Yuriko, Karigane, Daiki, Ootomo, Yukako, Kobayashi, Hiroshi, Morikawa, Takayuki, Otsu, Kinya, Kubota, Yoshiaki, Okamoto, Shinichiro, Goda, Nobuhito, Takubo, Keiyo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065231/ https://www.ncbi.nlm.nih.gov/pubmed/33745970 http://dx.doi.org/10.1016/j.jbc.2021.100563

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