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An optimized protocol for establishing a chronic stress model in mice
Chronic stress has adverse consequences on many organ systems and physiological processes. However, existing protocols show large variability in response and are not suitable for female mice. Here, we provide a step-by-step protocol for establishing a reliable chronic stress model in mice that can b...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065287/ https://www.ncbi.nlm.nih.gov/pubmed/33912847 http://dx.doi.org/10.1016/j.xpro.2021.100448 |
| _version_ | 1783682307560833024 |
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| author | Ip, Chi Kin |
| author_facet | Ip, Chi Kin |
| author_sort | Ip, Chi Kin |
| collection | PubMed |
| description | Chronic stress has adverse consequences on many organ systems and physiological processes. However, existing protocols show large variability in response and are not suitable for female mice. Here, we provide a step-by-step protocol for establishing a reliable chronic stress model in mice that can be used in a variety of physiological settings. This protocol has been tested to be effective to produce a consistent response to stress in several mouse strains (C57BL/6J, 129X1/SvJ, B6.V-Lepob/J) and both sexes. For complete details on the use and execution of this protocol, please refer to Ip et al. (2019). |
| format | Online Article Text |
| id | pubmed-8065287 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-80652872021-04-27 An optimized protocol for establishing a chronic stress model in mice Ip, Chi Kin STAR Protoc Protocol Chronic stress has adverse consequences on many organ systems and physiological processes. However, existing protocols show large variability in response and are not suitable for female mice. Here, we provide a step-by-step protocol for establishing a reliable chronic stress model in mice that can be used in a variety of physiological settings. This protocol has been tested to be effective to produce a consistent response to stress in several mouse strains (C57BL/6J, 129X1/SvJ, B6.V-Lepob/J) and both sexes. For complete details on the use and execution of this protocol, please refer to Ip et al. (2019). Elsevier 2021-04-12 /pmc/articles/PMC8065287/ /pubmed/33912847 http://dx.doi.org/10.1016/j.xpro.2021.100448 Text en Crown Copyright © 2021. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Protocol Ip, Chi Kin An optimized protocol for establishing a chronic stress model in mice |
| title | An optimized protocol for establishing a chronic stress model in mice |
| title_full | An optimized protocol for establishing a chronic stress model in mice |
| title_fullStr | An optimized protocol for establishing a chronic stress model in mice |
| title_full_unstemmed | An optimized protocol for establishing a chronic stress model in mice |
| title_short | An optimized protocol for establishing a chronic stress model in mice |
| title_sort | optimized protocol for establishing a chronic stress model in mice |
| topic | Protocol |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065287/ https://www.ncbi.nlm.nih.gov/pubmed/33912847 http://dx.doi.org/10.1016/j.xpro.2021.100448 |
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