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The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys
Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19. In rhesus monkey, SARS-CoV-2 invades the...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065334/ https://www.ncbi.nlm.nih.gov/pubmed/33895780 http://dx.doi.org/10.1038/s41392-021-00591-7 |
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| author | Jiao, Li Yang, Yun Yu, Wenhai Zhao, Yuan Long, Haiting Gao, Jiahong Ding, Kaiyun Ma, Chunxia Li, Jingmei Zhao, Siwen Wang, Haixuan Li, Haiyan Yang, Mengli Xu, Jingwen Wang, Junbin Yang, Jing Kuang, Dexuan Luo, Fangyu Qian, Xingli Xu, Longjiang Yin, Bin Liu, Wei Liu, Hongqi Lu, Shuaiyao Peng, Xiaozhong |
| author_facet | Jiao, Li Yang, Yun Yu, Wenhai Zhao, Yuan Long, Haiting Gao, Jiahong Ding, Kaiyun Ma, Chunxia Li, Jingmei Zhao, Siwen Wang, Haixuan Li, Haiyan Yang, Mengli Xu, Jingwen Wang, Junbin Yang, Jing Kuang, Dexuan Luo, Fangyu Qian, Xingli Xu, Longjiang Yin, Bin Liu, Wei Liu, Hongqi Lu, Shuaiyao Peng, Xiaozhong |
| author_sort | Jiao, Li |
| collection | PubMed |
| description | Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19. In rhesus monkey, SARS-CoV-2 invades the CNS primarily via the olfactory bulb. Thereafter, viruses rapidly spread to functional areas of the central nervous system, such as hippocampus, thalamus, and medulla oblongata. The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons, microglia, and astrocytes in the CNS. Consistently, SARS-CoV-2 infects neuro-derived SK-N-SH, glial-derived U251, and brain microvascular endothelial cells in vitro. To our knowledge, this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model, which provides important insights into the CNS-related pathogenesis of SARS-CoV-2. |
| format | Online Article Text |
| id | pubmed-8065334 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-80653342021-04-26 The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys Jiao, Li Yang, Yun Yu, Wenhai Zhao, Yuan Long, Haiting Gao, Jiahong Ding, Kaiyun Ma, Chunxia Li, Jingmei Zhao, Siwen Wang, Haixuan Li, Haiyan Yang, Mengli Xu, Jingwen Wang, Junbin Yang, Jing Kuang, Dexuan Luo, Fangyu Qian, Xingli Xu, Longjiang Yin, Bin Liu, Wei Liu, Hongqi Lu, Shuaiyao Peng, Xiaozhong Signal Transduct Target Ther Article Neurological manifestations are frequently reported in the COVID-19 patients. Neuromechanism of SARS-CoV-2 remains to be elucidated. In this study, we explored the mechanisms of SARS-CoV-2 neurotropism via our established non-human primate model of COVID-19. In rhesus monkey, SARS-CoV-2 invades the CNS primarily via the olfactory bulb. Thereafter, viruses rapidly spread to functional areas of the central nervous system, such as hippocampus, thalamus, and medulla oblongata. The infection of SARS-CoV-2 induces the inflammation possibly by targeting neurons, microglia, and astrocytes in the CNS. Consistently, SARS-CoV-2 infects neuro-derived SK-N-SH, glial-derived U251, and brain microvascular endothelial cells in vitro. To our knowledge, this is the first experimental evidence of SARS-CoV-2 neuroinvasion in the NHP model, which provides important insights into the CNS-related pathogenesis of SARS-CoV-2. Nature Publishing Group UK 2021-04-24 /pmc/articles/PMC8065334/ /pubmed/33895780 http://dx.doi.org/10.1038/s41392-021-00591-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Jiao, Li Yang, Yun Yu, Wenhai Zhao, Yuan Long, Haiting Gao, Jiahong Ding, Kaiyun Ma, Chunxia Li, Jingmei Zhao, Siwen Wang, Haixuan Li, Haiyan Yang, Mengli Xu, Jingwen Wang, Junbin Yang, Jing Kuang, Dexuan Luo, Fangyu Qian, Xingli Xu, Longjiang Yin, Bin Liu, Wei Liu, Hongqi Lu, Shuaiyao Peng, Xiaozhong The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys |
| title | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys |
| title_full | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys |
| title_fullStr | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys |
| title_full_unstemmed | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys |
| title_short | The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys |
| title_sort | olfactory route is a potential way for sars-cov-2 to invade the central nervous system of rhesus monkeys |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065334/ https://www.ncbi.nlm.nih.gov/pubmed/33895780 http://dx.doi.org/10.1038/s41392-021-00591-7 |
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