Complete Blood Count Analysis on Beef Cattle Exposed to Fescue Toxicity and Rumen-Protected Niacin Supplementation

SIMPLE SUMMARY: Fescue toxicity results from cattle consuming fungal (Ergot spp.) endophyte-infected tall fescue. Ergot alkaloids like ergovaline produce vasoconstriction in cattle. Our objectives were to analyze changes in complete blood count and performance due to ergot alkaloid detoxification in growing beef cattle and the effect of selecting dams tolerant or susceptible to fescue toxicity based on their tolerance index, measured through a genetic test currently available for beef producers. Furthermore, rumen-protected niacin supplementation is proposed as a potential alleviator for vasoconstriction produced by fescue toxicity. Therefore, we assessed the effects of consuming endophyte-infected tall fescue seeds in addition to rumen-protected niacin supplementation in offspring performance and hematological parameters. Signs for anemia were noticed in susceptible heifer offspring that did not receive rumen-protected niacin, whereas inflammation or infection was detected in tolerant steers that received niacin in their diet. Typical symptoms of heat stress and intoxication with ergot alkaloids were noticed in offspring. Our results suggest that susceptible heifer offspring might have a more active detox metabolism when under fescue toxicity. Findings from this study could be utilized as a new tool to help beef cattle producers to dampen the adverse effects of fescue toxicity. ABSTRACT: Offspring born to dams genetically tested for resistance to fescue toxicity were separated in groups based on their dams’ resistance level (tolerant vs. susceptible). Rumen-protected niacin (RPN) is proposed as a potential alleviator for vasoconstriction produced by fescue toxicity. Complete blood count (CBC) analysis was utilized for detection of significant responses to treatments applied. Our objectives were as follows: (a) to analyze changes in CBC due to fescue toxicity, maternal resistance level, and RPN in growing offspring; and (b) to assess the effects of maternal resistance level when consuming endophyte-infected tall fescue seeds in addition to RPN in offspring performance. Body weight, average daily gain, or health status were not improved by RPN or the genetic test to detect fescue toxicity resistance. Typical signs of alkaloids intoxication and heat stress were noticed in offspring. Particularly, rectal temperature was greater for susceptible control heifers. Results showed that susceptible control offspring presented signs of anemia denoted by low mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV). High levels of white blood cells (WBC) and basophils in combination to low neutrophils to lymphocytes ratio were the signs of infection or inflammation detected in the CBC analysis, especially in tolerant niacin steers. Furthermore, offspring of control heifers had a greater percentage of reticulocytes and RDW, denoting signs of anemia.