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Gut Microbiome of a Multiethnic Community Possessed No Predominant Microbiota

With increasing globalisation, various diets from around the world are readily available in global cities. This study aimed to verify if multiethnic dietary habits destabilised the gut microbiome in response to frequent changes, leading to readily colonisation of exogenous microbes. This may have he...

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Autores principales: Khine, Wei Wei Thwe, Teo, Anna Hui Ting, Loong, Lucas Wee Wei, Tan, Jarett Jun Hao, Ang, Clarabelle Geok Hui, Ng, Winnie, Lee, Chuen Neng, Zhu, Congju, Lau, Quek Choon, Lee, Yuan-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065435/
https://www.ncbi.nlm.nih.gov/pubmed/33805276
http://dx.doi.org/10.3390/microorganisms9040702
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author Khine, Wei Wei Thwe
Teo, Anna Hui Ting
Loong, Lucas Wee Wei
Tan, Jarett Jun Hao
Ang, Clarabelle Geok Hui
Ng, Winnie
Lee, Chuen Neng
Zhu, Congju
Lau, Quek Choon
Lee, Yuan-Kun
author_facet Khine, Wei Wei Thwe
Teo, Anna Hui Ting
Loong, Lucas Wee Wei
Tan, Jarett Jun Hao
Ang, Clarabelle Geok Hui
Ng, Winnie
Lee, Chuen Neng
Zhu, Congju
Lau, Quek Choon
Lee, Yuan-Kun
author_sort Khine, Wei Wei Thwe
collection PubMed
description With increasing globalisation, various diets from around the world are readily available in global cities. This study aimed to verify if multiethnic dietary habits destabilised the gut microbiome in response to frequent changes, leading to readily colonisation of exogenous microbes. This may have health implications. We profiled Singapore young adults of different ethnicities for dietary habits, faecal type, gut microbiome and cytokine levels. Subjects were challenged with Lactobacillus casei, and corresponding changes in microbiome and cytokines were evaluated. Here, we found that the majority of young adults had normal stool types (73% Bristol Scale Types 3 and 4) and faecal microbiome categorised into three clusters, irrespective of race and gender. Cluster 1 was dominated by Bacteroides, Cluster 2 by Prevotella, while Cluster 3 showed a marginal increase in Blautia, Ruminococaceae and Ruminococcus, without a predominant microbiota. These youngsters in the three faecal microbiome clusters preferred Western high sugary beverages, Southeast Asian plant-rich diet and Asian/Western diets in rotation, respectively. Multiethnic dietary habits (Cluster 3) led to a gut microbiome without predominant microbiota yet demonstrated colonisation resistance to Lactobacillus. Although Bacteroides and Prevotella are reported to be health-promoting but also risk factors for some illnesses, Singapore-style dietary rotation habits may alleviate Bacteroides and Prevotella associated ill effects. Different immunological outcome was observed during consumption of the lactobacilli among the three microbiome clusters.
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spelling pubmed-80654352021-04-25 Gut Microbiome of a Multiethnic Community Possessed No Predominant Microbiota Khine, Wei Wei Thwe Teo, Anna Hui Ting Loong, Lucas Wee Wei Tan, Jarett Jun Hao Ang, Clarabelle Geok Hui Ng, Winnie Lee, Chuen Neng Zhu, Congju Lau, Quek Choon Lee, Yuan-Kun Microorganisms Article With increasing globalisation, various diets from around the world are readily available in global cities. This study aimed to verify if multiethnic dietary habits destabilised the gut microbiome in response to frequent changes, leading to readily colonisation of exogenous microbes. This may have health implications. We profiled Singapore young adults of different ethnicities for dietary habits, faecal type, gut microbiome and cytokine levels. Subjects were challenged with Lactobacillus casei, and corresponding changes in microbiome and cytokines were evaluated. Here, we found that the majority of young adults had normal stool types (73% Bristol Scale Types 3 and 4) and faecal microbiome categorised into three clusters, irrespective of race and gender. Cluster 1 was dominated by Bacteroides, Cluster 2 by Prevotella, while Cluster 3 showed a marginal increase in Blautia, Ruminococaceae and Ruminococcus, without a predominant microbiota. These youngsters in the three faecal microbiome clusters preferred Western high sugary beverages, Southeast Asian plant-rich diet and Asian/Western diets in rotation, respectively. Multiethnic dietary habits (Cluster 3) led to a gut microbiome without predominant microbiota yet demonstrated colonisation resistance to Lactobacillus. Although Bacteroides and Prevotella are reported to be health-promoting but also risk factors for some illnesses, Singapore-style dietary rotation habits may alleviate Bacteroides and Prevotella associated ill effects. Different immunological outcome was observed during consumption of the lactobacilli among the three microbiome clusters. MDPI 2021-03-29 /pmc/articles/PMC8065435/ /pubmed/33805276 http://dx.doi.org/10.3390/microorganisms9040702 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Khine, Wei Wei Thwe
Teo, Anna Hui Ting
Loong, Lucas Wee Wei
Tan, Jarett Jun Hao
Ang, Clarabelle Geok Hui
Ng, Winnie
Lee, Chuen Neng
Zhu, Congju
Lau, Quek Choon
Lee, Yuan-Kun
Gut Microbiome of a Multiethnic Community Possessed No Predominant Microbiota
title Gut Microbiome of a Multiethnic Community Possessed No Predominant Microbiota
title_full Gut Microbiome of a Multiethnic Community Possessed No Predominant Microbiota
title_fullStr Gut Microbiome of a Multiethnic Community Possessed No Predominant Microbiota
title_full_unstemmed Gut Microbiome of a Multiethnic Community Possessed No Predominant Microbiota
title_short Gut Microbiome of a Multiethnic Community Possessed No Predominant Microbiota
title_sort gut microbiome of a multiethnic community possessed no predominant microbiota
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065435/
https://www.ncbi.nlm.nih.gov/pubmed/33805276
http://dx.doi.org/10.3390/microorganisms9040702
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