Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761(®))

Mild cognitive impairment (MCI) and dementia are clinically prevalent in the elderly. There is a high risk of cognitive decline in patients diagnosed with MCI or dementia. This review describes the effectiveness of Ginkgo biloba leaf special extract EGb 761(®) for the treatment of dementia syndromes...

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Autores principales: Tomino, Carlo, Ilari, Sara, Solfrizzi, Vincenzo, Malafoglia, Valentina, Zilio, Guglielmo, Russo, Patrizia, Proietti, Stefania, Marcolongo, Federica, Scapagnini, Giovanni, Muscoli, Carolina, Rossini, Paolo Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065464/
https://www.ncbi.nlm.nih.gov/pubmed/33915701
http://dx.doi.org/10.3390/ph14040305
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author Tomino, Carlo
Ilari, Sara
Solfrizzi, Vincenzo
Malafoglia, Valentina
Zilio, Guglielmo
Russo, Patrizia
Proietti, Stefania
Marcolongo, Federica
Scapagnini, Giovanni
Muscoli, Carolina
Rossini, Paolo Maria
author_facet Tomino, Carlo
Ilari, Sara
Solfrizzi, Vincenzo
Malafoglia, Valentina
Zilio, Guglielmo
Russo, Patrizia
Proietti, Stefania
Marcolongo, Federica
Scapagnini, Giovanni
Muscoli, Carolina
Rossini, Paolo Maria
author_sort Tomino, Carlo
collection PubMed
description Mild cognitive impairment (MCI) and dementia are clinically prevalent in the elderly. There is a high risk of cognitive decline in patients diagnosed with MCI or dementia. This review describes the effectiveness of Ginkgo biloba leaf special extract EGb 761(®) for the treatment of dementia syndromes and EGb 761(®) combination therapy with other medications for symptomatic dementia. This drug has shown convincing results, improving cognitive function, neuropsychiatric symptoms and consequent reduction of caregiver stress and maintenance of autonomy in patients with age-related cognitive decline, MCI and mild to moderate dementia. Currently, there is little evidence to support the combination therapy with anti-dementia drugs and, therefore, more evidence is needed to evaluate the role of EGb 761(®) in mixed therapy.
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spelling pubmed-80654642021-04-25 Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761(®)) Tomino, Carlo Ilari, Sara Solfrizzi, Vincenzo Malafoglia, Valentina Zilio, Guglielmo Russo, Patrizia Proietti, Stefania Marcolongo, Federica Scapagnini, Giovanni Muscoli, Carolina Rossini, Paolo Maria Pharmaceuticals (Basel) Review Mild cognitive impairment (MCI) and dementia are clinically prevalent in the elderly. There is a high risk of cognitive decline in patients diagnosed with MCI or dementia. This review describes the effectiveness of Ginkgo biloba leaf special extract EGb 761(®) for the treatment of dementia syndromes and EGb 761(®) combination therapy with other medications for symptomatic dementia. This drug has shown convincing results, improving cognitive function, neuropsychiatric symptoms and consequent reduction of caregiver stress and maintenance of autonomy in patients with age-related cognitive decline, MCI and mild to moderate dementia. Currently, there is little evidence to support the combination therapy with anti-dementia drugs and, therefore, more evidence is needed to evaluate the role of EGb 761(®) in mixed therapy. MDPI 2021-04-01 /pmc/articles/PMC8065464/ /pubmed/33915701 http://dx.doi.org/10.3390/ph14040305 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tomino, Carlo
Ilari, Sara
Solfrizzi, Vincenzo
Malafoglia, Valentina
Zilio, Guglielmo
Russo, Patrizia
Proietti, Stefania
Marcolongo, Federica
Scapagnini, Giovanni
Muscoli, Carolina
Rossini, Paolo Maria
Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761(®))
title Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761(®))
title_full Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761(®))
title_fullStr Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761(®))
title_full_unstemmed Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761(®))
title_short Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo biloba (EGb 761(®))
title_sort mild cognitive impairment and mild dementia: the role of ginkgo biloba (egb 761(®))
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065464/
https://www.ncbi.nlm.nih.gov/pubmed/33915701
http://dx.doi.org/10.3390/ph14040305
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