Cargando…

Neutralizing Monoclonal Anti-SARS-CoV-2 Antibodies Isolated from Immunized Rabbits Define Novel Vulnerable Spike-Protein Epitope

Monoclonal antibodies represent an important avenue for COVID-19 therapy and are routinely used for rapid and accessible diagnosis of SARS-CoV-2 infection. The recent emergence of SARS-CoV-2 genetic variants emphasized the need to enlarge the repertoire of antibodies that target diverse epitopes, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Makdasi, Efi, Levy, Yinon, Alcalay, Ron, Noy-Porat, Tal, Zahavy, Eran, Mechaly, Adva, Epstein, Eyal, Peretz, Eldar, Cohen, Hila, Bar-On, Liat, Chitlaru, Theodor, Cohen, Ofer, Glinert, Itai, Achdout, Hagit, Israely, Tomer, Rosenfeld, Ronit, Mazor, Ohad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065470/ https://www.ncbi.nlm.nih.gov/pubmed/33810465 http://dx.doi.org/10.3390/v13040566

Ejemplares similares

Characterization of antibody-antigen interactions using biolayer interferometry
por: Noy-Porat, Tal, et al.
Publicado: (2021)

Immunodominant Linear B-Cell Epitopes of SARS-CoV-2 Spike, Identified by Sera from K18-hACE2 Mice Infected with the WT or Variant Viruses
por: Levy, Yinon, et al.
Publicado: (2022)

A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
por: Noy-Porat, Tal, et al.
Publicado: (2020)

Spike vs nucleocapsid SARS-CoV-2 antigen detection: application in nasopharyngeal swab specimens
por: Barlev-Gross, Moria, et al.
Publicado: (2021)

Rapid and Sensitive Multiplex Assay for the Detection of B. anthracis Spores from Environmental Samples
por: Makdasi, Efi, et al.
Publicado: (2020)

Generation of recombinant mAbs to vaccinia virus displaying high affinity and potent neutralization
por: Noy-Porat, Tal, et al.
Publicado: (2023)

Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice
por: Bar-On, Liat, et al.
Publicado: (2022)

The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against viral variants
por: Makdasi, Efi, et al.
Publicado: (2021)

Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody
por: Rosenfeld, Ronit, et al.
Publicado: (2021)

Mice with induced pulmonary morbidities display severe lung inflammation and mortality following exposure to SARS-CoV-2
por: Falach, Reut, et al.
Publicado: (2021)

Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice
por: Noy-Porat, Tal, et al.
Publicado: (2021)

Novel Phage Display-Derived Anti-Abrin Antibodies Confer Post-Exposure Protection against Abrin Intoxication
por: Mechaly, Adva, et al.
Publicado: (2018)

Inhibition of Francisella tularensis phagocytosis using a novel anti-LPS scFv antibody fragment
por: Mechaly, Adva, et al.
Publicado: (2019)

Centaur antibodies: Engineered chimeric equine-human recombinant antibodies
por: Rosenfeld, Ronit, et al.
Publicado: (2022)

Implementation of Adenovirus-Mediated Pulmonary Expression of Human ACE2 in HLA Transgenic Mice Enables Establishment of a COVID-19 Murine Model for Assessment of Immune Responses to SARS-CoV-2 Infection
por: Chitlaru, Theodor, et al.
Publicado: (2021)

A Serological Snapshot of COVID-19 Initial Stages in Israel by a 6-Plex Antigen Array
por: Fisher, Morly, et al.
Publicado: (2021)

Fc-Independent Protection from SARS-CoV-2 Infection by Recombinant Human Monoclonal Antibodies
por: Noy-Porat, Tal, et al.
Publicado: (2021)

Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates
por: Noy-Porat, Tal, et al.
Publicado: (2016)

Iron-Modified Blood Culture Media Allow for the Rapid Diagnosis and Isolation of the Slow-Growing Pathogen Francisella tularensis
por: Makdasi, Efi, et al.
Publicado: (2022)

Neutralization of SARS-CoV-2 Variants by rVSV-ΔG-Spike-Elicited Human Sera
por: Yahalom-Ronen, Yfat, et al.
Publicado: (2022)

A Cell-Based Capture Assay for Rapid Virus Detection
por: Milrot, Elad, et al.
Publicado: (2020)

Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity
por: Achdout, Hagit, et al.
Publicado: (2021)

Influenza virus infection augments susceptibility to respiratory Yersinia pestis exposure and impacts the efficacy of antiplague antibiotic treatments
por: Vagima, Yaron, et al.
Publicado: (2020)

Isolation and Chimerization of a Highly Neutralizing Antibody Conferring Passive Protection against Lethal Bacillus anthracis Infection
por: Rosenfeld, Ronit, et al.
Publicado: (2009)

An Improvement in Diagnostic Blood Culture Conditions Allows for the Rapid Detection and Isolation of the Slow Growing Pathogen Yersinia pestis
por: Makdasi, Efi, et al.
Publicado: (2022)

TLR3 and TLR9 Agonists Improve Postexposure Vaccination Efficacy of Live Smallpox Vaccines
por: Israely, Tomer, et al.
Publicado: (2014)

A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
por: Yahalom-Ronen, Yfat, et al.
Publicado: (2020)

Induction of Innate Immune Response by TLR3 Agonist Protects Mice against SARS-CoV-2 Infection
por: Tamir, Hadas, et al.
Publicado: (2022)

Detection and infectivity potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) environmental contamination in isolation units and quarantine facilities
por: Ben-Shmuel, Amir, et al.
Publicado: (2020)

Preliminary nonclinical safety and immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs
por: Madar-Balakirski, Noa, et al.
Publicado: (2022)

SARS-CoV-2 receptor binding domain fusion protein efficiently neutralizes virus infection
por: Chaouat, Abigael Eva, et al.
Publicado: (2021)

Matrix Metalloproteinases Expression Is Associated with SARS-CoV-2-Induced Lung Pathology and Extracellular-Matrix Remodeling in K18-hACE2 Mice
por: Gutman, Hila, et al.
Publicado: (2022)

Identification of T-Cell Epitopes Using a Combined In-Silico and Experimental Approach in a Mouse Model for SARS-CoV-2
por: Erez, Noam, et al.
Publicado: (2023)

Highly Specific Monoclonal Antibody Targeting the Botulinum Neurotoxin Type E Exposed SNAP-25 Neoepitope
por: Mechaly, Adva, et al.
Publicado: (2022)

Anti-SARS-CoV-2 immunoadhesin remains effective against Omicron and other emerging variants of concern
por: Cohen-Dvashi, Hadas, et al.
Publicado: (2022)

Differential Response Following Infection of Mouse CNS with Virulent and Attenuated Vaccinia Virus Strains
por: Israely, Tomer, et al.
Publicado: (2019)

Antiviral activity of glucosylceramide synthase inhibitors in alphavirus infection of the central nervous system
por: Avraham, Roy, et al.
Publicado: (2023)

Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and influenza virus
por: Vitner, Einat B., et al.
Publicado: (2021)

A rapid high-throughput sequencing-based approach for the identification of unknown bacterial pathogens in whole blood
por: Israeli, Ofir, et al.
Publicado: (2020)

Improved production of monoclonal antibodies against the LcrV antigen of Yersinia pestis using FACS-aided hybridoma selection
por: Sittner, Assa, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hovg23mvjs0ek53qcmcgod9e36