Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections

Carbapenem-resistant Enterobacterales (CRE) are included in the list of the most threatening antibiotic resistance microorganisms, being responsible for often insurmountable therapeutic issues, especially in hospitalized patients and immunocompromised individuals and patients in intensive care units...

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Autores principales: Vrancianu, Corneliu Ovidiu, Dobre, Elena Georgiana, Gheorghe, Irina, Barbu, Ilda, Cristian, Roxana Elena, Chifiriuc, Mariana Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065494/
https://www.ncbi.nlm.nih.gov/pubmed/33807464
http://dx.doi.org/10.3390/microorganisms9040730
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author Vrancianu, Corneliu Ovidiu
Dobre, Elena Georgiana
Gheorghe, Irina
Barbu, Ilda
Cristian, Roxana Elena
Chifiriuc, Mariana Carmen
author_facet Vrancianu, Corneliu Ovidiu
Dobre, Elena Georgiana
Gheorghe, Irina
Barbu, Ilda
Cristian, Roxana Elena
Chifiriuc, Mariana Carmen
author_sort Vrancianu, Corneliu Ovidiu
collection PubMed
description Carbapenem-resistant Enterobacterales (CRE) are included in the list of the most threatening antibiotic resistance microorganisms, being responsible for often insurmountable therapeutic issues, especially in hospitalized patients and immunocompromised individuals and patients in intensive care units. The enzymatic resistance to carbapenems is encoded by different β-lactamases belonging to A, B or D Ambler class. Besides compromising the activity of last-resort antibiotics, CRE have spread from the clinical to the environmental sectors, in all geographic regions. The purpose of this review is to present present and future perspectives on CRE-associated infections treatment.
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spelling pubmed-80654942021-04-25 Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections Vrancianu, Corneliu Ovidiu Dobre, Elena Georgiana Gheorghe, Irina Barbu, Ilda Cristian, Roxana Elena Chifiriuc, Mariana Carmen Microorganisms Review Carbapenem-resistant Enterobacterales (CRE) are included in the list of the most threatening antibiotic resistance microorganisms, being responsible for often insurmountable therapeutic issues, especially in hospitalized patients and immunocompromised individuals and patients in intensive care units. The enzymatic resistance to carbapenems is encoded by different β-lactamases belonging to A, B or D Ambler class. Besides compromising the activity of last-resort antibiotics, CRE have spread from the clinical to the environmental sectors, in all geographic regions. The purpose of this review is to present present and future perspectives on CRE-associated infections treatment. MDPI 2021-03-31 /pmc/articles/PMC8065494/ /pubmed/33807464 http://dx.doi.org/10.3390/microorganisms9040730 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vrancianu, Corneliu Ovidiu
Dobre, Elena Georgiana
Gheorghe, Irina
Barbu, Ilda
Cristian, Roxana Elena
Chifiriuc, Mariana Carmen
Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections
title Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections
title_full Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections
title_fullStr Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections
title_full_unstemmed Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections
title_short Present and Future Perspectives on Therapeutic Options for Carbapenemase-Producing Enterobacterales Infections
title_sort present and future perspectives on therapeutic options for carbapenemase-producing enterobacterales infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065494/
https://www.ncbi.nlm.nih.gov/pubmed/33807464
http://dx.doi.org/10.3390/microorganisms9040730
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