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LTβR Signaling Controls Lymphatic Migration of Immune Cells

The pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis. Recently, LTβR signaling in endothelial cells has been revealed to regulate...

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Autores principales: Piao, Wenji, Kasinath, Vivek, Saxena, Vikas, Lakhan, Ram, Iyyathurai, Jegan, Bromberg, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065509/
https://www.ncbi.nlm.nih.gov/pubmed/33805271
http://dx.doi.org/10.3390/cells10040747
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author Piao, Wenji
Kasinath, Vivek
Saxena, Vikas
Lakhan, Ram
Iyyathurai, Jegan
Bromberg, Jonathan S.
author_facet Piao, Wenji
Kasinath, Vivek
Saxena, Vikas
Lakhan, Ram
Iyyathurai, Jegan
Bromberg, Jonathan S.
author_sort Piao, Wenji
collection PubMed
description The pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis. Recently, LTβR signaling in endothelial cells has been revealed to regulate immune cell migration. Signaling through LTβR is comprised of both the canonical and non-canonical-nuclear factor κB (NF-κB) pathways, which induce chemokines, cytokines, and cell adhesion molecules. Here, we focus on the novel functions of LTβR signaling in lymphatic endothelial cells for migration of regulatory T cells (Tregs), and specific targeting of LTβR signaling for potential therapeutics in transplantation and cancer patient survival.
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spelling pubmed-80655092021-04-25 LTβR Signaling Controls Lymphatic Migration of Immune Cells Piao, Wenji Kasinath, Vivek Saxena, Vikas Lakhan, Ram Iyyathurai, Jegan Bromberg, Jonathan S. Cells Review The pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis. Recently, LTβR signaling in endothelial cells has been revealed to regulate immune cell migration. Signaling through LTβR is comprised of both the canonical and non-canonical-nuclear factor κB (NF-κB) pathways, which induce chemokines, cytokines, and cell adhesion molecules. Here, we focus on the novel functions of LTβR signaling in lymphatic endothelial cells for migration of regulatory T cells (Tregs), and specific targeting of LTβR signaling for potential therapeutics in transplantation and cancer patient survival. MDPI 2021-03-29 /pmc/articles/PMC8065509/ /pubmed/33805271 http://dx.doi.org/10.3390/cells10040747 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Review
Piao, Wenji
Kasinath, Vivek
Saxena, Vikas
Lakhan, Ram
Iyyathurai, Jegan
Bromberg, Jonathan S.
LTβR Signaling Controls Lymphatic Migration of Immune Cells
title LTβR Signaling Controls Lymphatic Migration of Immune Cells
title_full LTβR Signaling Controls Lymphatic Migration of Immune Cells
title_fullStr LTβR Signaling Controls Lymphatic Migration of Immune Cells
title_full_unstemmed LTβR Signaling Controls Lymphatic Migration of Immune Cells
title_short LTβR Signaling Controls Lymphatic Migration of Immune Cells
title_sort ltβr signaling controls lymphatic migration of immune cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065509/
https://www.ncbi.nlm.nih.gov/pubmed/33805271
http://dx.doi.org/10.3390/cells10040747
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