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LTβR Signaling Controls Lymphatic Migration of Immune Cells
The pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis. Recently, LTβR signaling in endothelial cells has been revealed to regulate...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065509/ https://www.ncbi.nlm.nih.gov/pubmed/33805271 http://dx.doi.org/10.3390/cells10040747 |
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author | Piao, Wenji Kasinath, Vivek Saxena, Vikas Lakhan, Ram Iyyathurai, Jegan Bromberg, Jonathan S. |
author_facet | Piao, Wenji Kasinath, Vivek Saxena, Vikas Lakhan, Ram Iyyathurai, Jegan Bromberg, Jonathan S. |
author_sort | Piao, Wenji |
collection | PubMed |
description | The pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis. Recently, LTβR signaling in endothelial cells has been revealed to regulate immune cell migration. Signaling through LTβR is comprised of both the canonical and non-canonical-nuclear factor κB (NF-κB) pathways, which induce chemokines, cytokines, and cell adhesion molecules. Here, we focus on the novel functions of LTβR signaling in lymphatic endothelial cells for migration of regulatory T cells (Tregs), and specific targeting of LTβR signaling for potential therapeutics in transplantation and cancer patient survival. |
format | Online Article Text |
id | pubmed-8065509 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80655092021-04-25 LTβR Signaling Controls Lymphatic Migration of Immune Cells Piao, Wenji Kasinath, Vivek Saxena, Vikas Lakhan, Ram Iyyathurai, Jegan Bromberg, Jonathan S. Cells Review The pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis. Recently, LTβR signaling in endothelial cells has been revealed to regulate immune cell migration. Signaling through LTβR is comprised of both the canonical and non-canonical-nuclear factor κB (NF-κB) pathways, which induce chemokines, cytokines, and cell adhesion molecules. Here, we focus on the novel functions of LTβR signaling in lymphatic endothelial cells for migration of regulatory T cells (Tregs), and specific targeting of LTβR signaling for potential therapeutics in transplantation and cancer patient survival. MDPI 2021-03-29 /pmc/articles/PMC8065509/ /pubmed/33805271 http://dx.doi.org/10.3390/cells10040747 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Piao, Wenji Kasinath, Vivek Saxena, Vikas Lakhan, Ram Iyyathurai, Jegan Bromberg, Jonathan S. LTβR Signaling Controls Lymphatic Migration of Immune Cells |
title | LTβR Signaling Controls Lymphatic Migration of Immune Cells |
title_full | LTβR Signaling Controls Lymphatic Migration of Immune Cells |
title_fullStr | LTβR Signaling Controls Lymphatic Migration of Immune Cells |
title_full_unstemmed | LTβR Signaling Controls Lymphatic Migration of Immune Cells |
title_short | LTβR Signaling Controls Lymphatic Migration of Immune Cells |
title_sort | ltβr signaling controls lymphatic migration of immune cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065509/ https://www.ncbi.nlm.nih.gov/pubmed/33805271 http://dx.doi.org/10.3390/cells10040747 |
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