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Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?

The emergence of bacterial resistance to traditional small-molecule antibiotics is fueling the search for innovative strategies to treat infections. Inhibiting the expression of essential bacterial genes using antisense oligonucleotides (ASOs), particularly composed of nucleic acid mimics (NAMs), ha...

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Detalles Bibliográficos
Autores principales:	Pereira, Sara, Yao, Ruwei, Gomes, Mariana, Jørgensen, Per Trolle, Wengel, Jesper, Azevedo, Nuno Filipe, Sobral Santos, Rita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065541/ https://www.ncbi.nlm.nih.gov/pubmed/33916701 http://dx.doi.org/10.3390/antibiotics10040379

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