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Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent

Neurological disorders are diseases of the central and peripheral nervous system that affect millions of people, and the numbers are rising gradually. In the pathogenesis of neurodegenerative diseases, the roles of many signaling pathways were elucidated; however, the exact pathophysiology of neurol...

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Autores principales: Bahbah, Eshak I., Ghozy, Sherief, Attia, Mohamed S., Negida, Ahmed, Emran, Talha Bin, Mitra, Saikat, Albadrani, Ghadeer M., Abdel-Daim, Mohamed M., Uddin, Md. Sahab, Simal-Gandara, Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065559/
https://www.ncbi.nlm.nih.gov/pubmed/33916730
http://dx.doi.org/10.3390/md19040201
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author Bahbah, Eshak I.
Ghozy, Sherief
Attia, Mohamed S.
Negida, Ahmed
Emran, Talha Bin
Mitra, Saikat
Albadrani, Ghadeer M.
Abdel-Daim, Mohamed M.
Uddin, Md. Sahab
Simal-Gandara, Jesus
author_facet Bahbah, Eshak I.
Ghozy, Sherief
Attia, Mohamed S.
Negida, Ahmed
Emran, Talha Bin
Mitra, Saikat
Albadrani, Ghadeer M.
Abdel-Daim, Mohamed M.
Uddin, Md. Sahab
Simal-Gandara, Jesus
author_sort Bahbah, Eshak I.
collection PubMed
description Neurological disorders are diseases of the central and peripheral nervous system that affect millions of people, and the numbers are rising gradually. In the pathogenesis of neurodegenerative diseases, the roles of many signaling pathways were elucidated; however, the exact pathophysiology of neurological disorders and possible effective therapeutics have not yet been precisely identified. This necessitates developing multi-target treatments, which would simultaneously modulate neuroinflammation, apoptosis, and oxidative stress. The present review aims to explore the potential therapeutic use of astaxanthin (ASX) in neurological and neuroinflammatory diseases. ASX, a member of the xanthophyll group, was found to be a promising therapeutic anti-inflammatory agent for many neurological disorders, including cerebral ischemia, Parkinson’s disease, Alzheimer’s disease, autism, and neuropathic pain. An effective drug delivery system of ASX should be developed and further tested by appropriate clinical trials.
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spelling pubmed-80655592021-04-25 Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent Bahbah, Eshak I. Ghozy, Sherief Attia, Mohamed S. Negida, Ahmed Emran, Talha Bin Mitra, Saikat Albadrani, Ghadeer M. Abdel-Daim, Mohamed M. Uddin, Md. Sahab Simal-Gandara, Jesus Mar Drugs Review Neurological disorders are diseases of the central and peripheral nervous system that affect millions of people, and the numbers are rising gradually. In the pathogenesis of neurodegenerative diseases, the roles of many signaling pathways were elucidated; however, the exact pathophysiology of neurological disorders and possible effective therapeutics have not yet been precisely identified. This necessitates developing multi-target treatments, which would simultaneously modulate neuroinflammation, apoptosis, and oxidative stress. The present review aims to explore the potential therapeutic use of astaxanthin (ASX) in neurological and neuroinflammatory diseases. ASX, a member of the xanthophyll group, was found to be a promising therapeutic anti-inflammatory agent for many neurological disorders, including cerebral ischemia, Parkinson’s disease, Alzheimer’s disease, autism, and neuropathic pain. An effective drug delivery system of ASX should be developed and further tested by appropriate clinical trials. MDPI 2021-04-03 /pmc/articles/PMC8065559/ /pubmed/33916730 http://dx.doi.org/10.3390/md19040201 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bahbah, Eshak I.
Ghozy, Sherief
Attia, Mohamed S.
Negida, Ahmed
Emran, Talha Bin
Mitra, Saikat
Albadrani, Ghadeer M.
Abdel-Daim, Mohamed M.
Uddin, Md. Sahab
Simal-Gandara, Jesus
Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent
title Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent
title_full Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent
title_fullStr Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent
title_full_unstemmed Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent
title_short Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent
title_sort molecular mechanisms of astaxanthin as a potential neurotherapeutic agent
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065559/
https://www.ncbi.nlm.nih.gov/pubmed/33916730
http://dx.doi.org/10.3390/md19040201
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