In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?

The discovery of sodium taurocholate co-transporting polypeptide (NTCP) as a hepatitis B (HBV) and delta virus (HDV) entry receptor has encouraged the development of new animal models of infection. This review provides an overview of the different in vivo models that are currently available to study...

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Detalles Bibliográficos
Autores principales: Giersch, Katja, Dandri, Maura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065588/
https://www.ncbi.nlm.nih.gov/pubmed/33807170
http://dx.doi.org/10.3390/v13040588
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author Giersch, Katja
Dandri, Maura
author_facet Giersch, Katja
Dandri, Maura
author_sort Giersch, Katja
collection PubMed
description The discovery of sodium taurocholate co-transporting polypeptide (NTCP) as a hepatitis B (HBV) and delta virus (HDV) entry receptor has encouraged the development of new animal models of infection. This review provides an overview of the different in vivo models that are currently available to study HDV either in the absence or presence of HBV. By presenting new advances and remaining drawbacks, we will discuss human host factors which, in addition to NTCP, need to be investigated or identified to enable a persistent HDV infection in murine hepatocytes. Detailed knowledge on species-specific factors involved in HDV persistence also shall contribute to the development of therapeutic strategies.
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spelling pubmed-80655882021-04-25 In Vivo Models of HDV Infection: Is Humanizing NTCP Enough? Giersch, Katja Dandri, Maura Viruses Review The discovery of sodium taurocholate co-transporting polypeptide (NTCP) as a hepatitis B (HBV) and delta virus (HDV) entry receptor has encouraged the development of new animal models of infection. This review provides an overview of the different in vivo models that are currently available to study HDV either in the absence or presence of HBV. By presenting new advances and remaining drawbacks, we will discuss human host factors which, in addition to NTCP, need to be investigated or identified to enable a persistent HDV infection in murine hepatocytes. Detailed knowledge on species-specific factors involved in HDV persistence also shall contribute to the development of therapeutic strategies. MDPI 2021-03-31 /pmc/articles/PMC8065588/ /pubmed/33807170 http://dx.doi.org/10.3390/v13040588 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Giersch, Katja
Dandri, Maura
In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?
title In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?
title_full In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?
title_fullStr In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?
title_full_unstemmed In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?
title_short In Vivo Models of HDV Infection: Is Humanizing NTCP Enough?
title_sort in vivo models of hdv infection: is humanizing ntcp enough?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065588/
https://www.ncbi.nlm.nih.gov/pubmed/33807170
http://dx.doi.org/10.3390/v13040588
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