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Loss of p16: A Bouncer of the Immunological Surveillance?

p16(INK4A) (hereafter called p16) is an important tumor suppressor protein frequently suppressed in human cancer and highly upregulated in many types of senescence. Although its role as a cell cycle regulator is very well delineated, little is known about its other non-cell cycle-related roles. Impo...

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Autores principales: Leon, Kelly E., Tangudu, Naveen Kumar, Aird, Katherine M., Buj, Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065641/
https://www.ncbi.nlm.nih.gov/pubmed/33918220
http://dx.doi.org/10.3390/life11040309
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author Leon, Kelly E.
Tangudu, Naveen Kumar
Aird, Katherine M.
Buj, Raquel
author_facet Leon, Kelly E.
Tangudu, Naveen Kumar
Aird, Katherine M.
Buj, Raquel
author_sort Leon, Kelly E.
collection PubMed
description p16(INK4A) (hereafter called p16) is an important tumor suppressor protein frequently suppressed in human cancer and highly upregulated in many types of senescence. Although its role as a cell cycle regulator is very well delineated, little is known about its other non-cell cycle-related roles. Importantly, recent correlative studies suggest that p16 may be a regulator of tissue immunological surveillance through the transcriptional regulation of different chemokines, interleukins and other factors secreted as part of the senescence-associated secretory phenotype (SASP). Here, we summarize the current evidence supporting the hypothesis that p16 is a regulator of tumor immunity.
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spelling pubmed-80656412021-04-25 Loss of p16: A Bouncer of the Immunological Surveillance? Leon, Kelly E. Tangudu, Naveen Kumar Aird, Katherine M. Buj, Raquel Life (Basel) Review p16(INK4A) (hereafter called p16) is an important tumor suppressor protein frequently suppressed in human cancer and highly upregulated in many types of senescence. Although its role as a cell cycle regulator is very well delineated, little is known about its other non-cell cycle-related roles. Importantly, recent correlative studies suggest that p16 may be a regulator of tissue immunological surveillance through the transcriptional regulation of different chemokines, interleukins and other factors secreted as part of the senescence-associated secretory phenotype (SASP). Here, we summarize the current evidence supporting the hypothesis that p16 is a regulator of tumor immunity. MDPI 2021-04-02 /pmc/articles/PMC8065641/ /pubmed/33918220 http://dx.doi.org/10.3390/life11040309 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Leon, Kelly E.
Tangudu, Naveen Kumar
Aird, Katherine M.
Buj, Raquel
Loss of p16: A Bouncer of the Immunological Surveillance?
title Loss of p16: A Bouncer of the Immunological Surveillance?
title_full Loss of p16: A Bouncer of the Immunological Surveillance?
title_fullStr Loss of p16: A Bouncer of the Immunological Surveillance?
title_full_unstemmed Loss of p16: A Bouncer of the Immunological Surveillance?
title_short Loss of p16: A Bouncer of the Immunological Surveillance?
title_sort loss of p16: a bouncer of the immunological surveillance?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065641/
https://www.ncbi.nlm.nih.gov/pubmed/33918220
http://dx.doi.org/10.3390/life11040309
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