Cargando…

Establishment of a Genetically Confirmed Breeding Colony of Mastomys natalensis from Wild-Caught Founders from West Africa

Mastomys natalensis are a ubiquitous and often dominant rodent across sub-Saharan Africa. Importantly, they are a natural reservoir for microbial pathogens including Lassa virus (LASV), the etiological agent of Lassa fever in humans. Lassa-infected rodents have been documented across West Africa and...

Descripción completa

Detalles Bibliográficos
Autores principales: Safronetz, David, Rosenke, Kyle, Fischer, Robert J., LaCasse, Rachel A., Scott, Dana P., Saturday, Greg, Hanley, Patrick W., Maiga, Ousmane, Sogoba, Nafomon, Schwan, Tom G., Feldmann, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065687/
https://www.ncbi.nlm.nih.gov/pubmed/33807214
http://dx.doi.org/10.3390/v13040590
_version_ 1783682399261949952
author Safronetz, David
Rosenke, Kyle
Fischer, Robert J.
LaCasse, Rachel A.
Scott, Dana P.
Saturday, Greg
Hanley, Patrick W.
Maiga, Ousmane
Sogoba, Nafomon
Schwan, Tom G.
Feldmann, Heinz
author_facet Safronetz, David
Rosenke, Kyle
Fischer, Robert J.
LaCasse, Rachel A.
Scott, Dana P.
Saturday, Greg
Hanley, Patrick W.
Maiga, Ousmane
Sogoba, Nafomon
Schwan, Tom G.
Feldmann, Heinz
author_sort Safronetz, David
collection PubMed
description Mastomys natalensis are a ubiquitous and often dominant rodent across sub-Saharan Africa. Importantly, they are a natural reservoir for microbial pathogens including Lassa virus (LASV), the etiological agent of Lassa fever in humans. Lassa-infected rodents have been documented across West Africa and coincide with regions where annual outbreaks occur. Zoonotic transmission to humans most often occurs directly from infected rodents. Little is known about LASV infection kinetics and transmissibility in M. natalensis, primarily due to available animals. Here, we describe the establishment of a laboratory breeding colony of genetically confirmed M. natalensis from wild-captured rodents. This colony will provide a convenient source of animals to study LASV and other emerging pathogens that utilize M. natalensis in their enzootic lifecycles.
format Online
Article
Text
id pubmed-8065687
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-80656872021-04-25 Establishment of a Genetically Confirmed Breeding Colony of Mastomys natalensis from Wild-Caught Founders from West Africa Safronetz, David Rosenke, Kyle Fischer, Robert J. LaCasse, Rachel A. Scott, Dana P. Saturday, Greg Hanley, Patrick W. Maiga, Ousmane Sogoba, Nafomon Schwan, Tom G. Feldmann, Heinz Viruses Article Mastomys natalensis are a ubiquitous and often dominant rodent across sub-Saharan Africa. Importantly, they are a natural reservoir for microbial pathogens including Lassa virus (LASV), the etiological agent of Lassa fever in humans. Lassa-infected rodents have been documented across West Africa and coincide with regions where annual outbreaks occur. Zoonotic transmission to humans most often occurs directly from infected rodents. Little is known about LASV infection kinetics and transmissibility in M. natalensis, primarily due to available animals. Here, we describe the establishment of a laboratory breeding colony of genetically confirmed M. natalensis from wild-captured rodents. This colony will provide a convenient source of animals to study LASV and other emerging pathogens that utilize M. natalensis in their enzootic lifecycles. MDPI 2021-03-31 /pmc/articles/PMC8065687/ /pubmed/33807214 http://dx.doi.org/10.3390/v13040590 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Safronetz, David
Rosenke, Kyle
Fischer, Robert J.
LaCasse, Rachel A.
Scott, Dana P.
Saturday, Greg
Hanley, Patrick W.
Maiga, Ousmane
Sogoba, Nafomon
Schwan, Tom G.
Feldmann, Heinz
Establishment of a Genetically Confirmed Breeding Colony of Mastomys natalensis from Wild-Caught Founders from West Africa
title Establishment of a Genetically Confirmed Breeding Colony of Mastomys natalensis from Wild-Caught Founders from West Africa
title_full Establishment of a Genetically Confirmed Breeding Colony of Mastomys natalensis from Wild-Caught Founders from West Africa
title_fullStr Establishment of a Genetically Confirmed Breeding Colony of Mastomys natalensis from Wild-Caught Founders from West Africa
title_full_unstemmed Establishment of a Genetically Confirmed Breeding Colony of Mastomys natalensis from Wild-Caught Founders from West Africa
title_short Establishment of a Genetically Confirmed Breeding Colony of Mastomys natalensis from Wild-Caught Founders from West Africa
title_sort establishment of a genetically confirmed breeding colony of mastomys natalensis from wild-caught founders from west africa
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065687/
https://www.ncbi.nlm.nih.gov/pubmed/33807214
http://dx.doi.org/10.3390/v13040590
work_keys_str_mv AT safronetzdavid establishmentofageneticallyconfirmedbreedingcolonyofmastomysnatalensisfromwildcaughtfoundersfromwestafrica
AT rosenkekyle establishmentofageneticallyconfirmedbreedingcolonyofmastomysnatalensisfromwildcaughtfoundersfromwestafrica
AT fischerrobertj establishmentofageneticallyconfirmedbreedingcolonyofmastomysnatalensisfromwildcaughtfoundersfromwestafrica
AT lacasserachela establishmentofageneticallyconfirmedbreedingcolonyofmastomysnatalensisfromwildcaughtfoundersfromwestafrica
AT scottdanap establishmentofageneticallyconfirmedbreedingcolonyofmastomysnatalensisfromwildcaughtfoundersfromwestafrica
AT saturdaygreg establishmentofageneticallyconfirmedbreedingcolonyofmastomysnatalensisfromwildcaughtfoundersfromwestafrica
AT hanleypatrickw establishmentofageneticallyconfirmedbreedingcolonyofmastomysnatalensisfromwildcaughtfoundersfromwestafrica
AT maigaousmane establishmentofageneticallyconfirmedbreedingcolonyofmastomysnatalensisfromwildcaughtfoundersfromwestafrica
AT sogobanafomon establishmentofageneticallyconfirmedbreedingcolonyofmastomysnatalensisfromwildcaughtfoundersfromwestafrica
AT schwantomg establishmentofageneticallyconfirmedbreedingcolonyofmastomysnatalensisfromwildcaughtfoundersfromwestafrica
AT feldmannheinz establishmentofageneticallyconfirmedbreedingcolonyofmastomysnatalensisfromwildcaughtfoundersfromwestafrica