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Peripancreatic Adipose Tissue Remodeling and Inflammation during High Fat Intake of Palm Oils or Lard in Rats

Excessive fat consumption leads to the development of ectopic adipose tissues, affecting the organs they surround. Peripancreatic adipose tissue is implicated in glucose homeostasis regulation and can be impaired in obesity. High palm oil consumption’s effects on health are still debated. We hypothe...

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Autores principales: Laget, Jonas, Djohan, Youzan Ferdinand, Jeanson, Laura, Muyor, Karen, Badia, Eric, Cristol, Jean Paul, Coudray, Charles, Feillet-Coudray, Christine, Vigor, Claire, Oger, Camille, Galano, Jean-Marie, Durand, Thierry, Lajoix, Anne-Dominique, Gayrard, Nathalie, Jover, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065769/
https://www.ncbi.nlm.nih.gov/pubmed/33808251
http://dx.doi.org/10.3390/nu13041134
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author Laget, Jonas
Djohan, Youzan Ferdinand
Jeanson, Laura
Muyor, Karen
Badia, Eric
Cristol, Jean Paul
Coudray, Charles
Feillet-Coudray, Christine
Vigor, Claire
Oger, Camille
Galano, Jean-Marie
Durand, Thierry
Lajoix, Anne-Dominique
Gayrard, Nathalie
Jover, Bernard
author_facet Laget, Jonas
Djohan, Youzan Ferdinand
Jeanson, Laura
Muyor, Karen
Badia, Eric
Cristol, Jean Paul
Coudray, Charles
Feillet-Coudray, Christine
Vigor, Claire
Oger, Camille
Galano, Jean-Marie
Durand, Thierry
Lajoix, Anne-Dominique
Gayrard, Nathalie
Jover, Bernard
author_sort Laget, Jonas
collection PubMed
description Excessive fat consumption leads to the development of ectopic adipose tissues, affecting the organs they surround. Peripancreatic adipose tissue is implicated in glucose homeostasis regulation and can be impaired in obesity. High palm oil consumption’s effects on health are still debated. We hypothesised that crude and refined palm oil high-fat feeding may have contrasting effects on peripancreatic adipocyte hypertrophy, inflammation and lipid oxidation compound production in obese rats. In Wistar rats, morphological changes, inflammation and isoprostanoid production following oxidative stress were assessed in peripancreatic adipose tissue after 12 weeks of diets enriched in crude or refined palm oil or lard (56% energy from fat in each case) versus a standard chow diet (11% energy from fat). Epididymal white and periaortic brown adipose tissues were also included in the study. A refined palm oil diet disturbed glucose homeostasis and promoted lipid deposition in periaortic locations, as well as adipocyte hypertrophy, macrophage infiltration and isoprostanoid (5-F(2c)-isoprostane and 7(RS)-ST-Δ(8)-11-dihomo-isofuran) production in peripancreatic adipose tissue. Crude palm oil induced a lower impact on adipose deposits than its refined form and lard. Our results show that the antioxidant composition of crude palm oil may have a protective effect on ectopic adipose tissues under the condition of excessive fat intake.
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spelling pubmed-80657692021-04-25 Peripancreatic Adipose Tissue Remodeling and Inflammation during High Fat Intake of Palm Oils or Lard in Rats Laget, Jonas Djohan, Youzan Ferdinand Jeanson, Laura Muyor, Karen Badia, Eric Cristol, Jean Paul Coudray, Charles Feillet-Coudray, Christine Vigor, Claire Oger, Camille Galano, Jean-Marie Durand, Thierry Lajoix, Anne-Dominique Gayrard, Nathalie Jover, Bernard Nutrients Article Excessive fat consumption leads to the development of ectopic adipose tissues, affecting the organs they surround. Peripancreatic adipose tissue is implicated in glucose homeostasis regulation and can be impaired in obesity. High palm oil consumption’s effects on health are still debated. We hypothesised that crude and refined palm oil high-fat feeding may have contrasting effects on peripancreatic adipocyte hypertrophy, inflammation and lipid oxidation compound production in obese rats. In Wistar rats, morphological changes, inflammation and isoprostanoid production following oxidative stress were assessed in peripancreatic adipose tissue after 12 weeks of diets enriched in crude or refined palm oil or lard (56% energy from fat in each case) versus a standard chow diet (11% energy from fat). Epididymal white and periaortic brown adipose tissues were also included in the study. A refined palm oil diet disturbed glucose homeostasis and promoted lipid deposition in periaortic locations, as well as adipocyte hypertrophy, macrophage infiltration and isoprostanoid (5-F(2c)-isoprostane and 7(RS)-ST-Δ(8)-11-dihomo-isofuran) production in peripancreatic adipose tissue. Crude palm oil induced a lower impact on adipose deposits than its refined form and lard. Our results show that the antioxidant composition of crude palm oil may have a protective effect on ectopic adipose tissues under the condition of excessive fat intake. MDPI 2021-03-30 /pmc/articles/PMC8065769/ /pubmed/33808251 http://dx.doi.org/10.3390/nu13041134 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Laget, Jonas
Djohan, Youzan Ferdinand
Jeanson, Laura
Muyor, Karen
Badia, Eric
Cristol, Jean Paul
Coudray, Charles
Feillet-Coudray, Christine
Vigor, Claire
Oger, Camille
Galano, Jean-Marie
Durand, Thierry
Lajoix, Anne-Dominique
Gayrard, Nathalie
Jover, Bernard
Peripancreatic Adipose Tissue Remodeling and Inflammation during High Fat Intake of Palm Oils or Lard in Rats
title Peripancreatic Adipose Tissue Remodeling and Inflammation during High Fat Intake of Palm Oils or Lard in Rats
title_full Peripancreatic Adipose Tissue Remodeling and Inflammation during High Fat Intake of Palm Oils or Lard in Rats
title_fullStr Peripancreatic Adipose Tissue Remodeling and Inflammation during High Fat Intake of Palm Oils or Lard in Rats
title_full_unstemmed Peripancreatic Adipose Tissue Remodeling and Inflammation during High Fat Intake of Palm Oils or Lard in Rats
title_short Peripancreatic Adipose Tissue Remodeling and Inflammation during High Fat Intake of Palm Oils or Lard in Rats
title_sort peripancreatic adipose tissue remodeling and inflammation during high fat intake of palm oils or lard in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065769/
https://www.ncbi.nlm.nih.gov/pubmed/33808251
http://dx.doi.org/10.3390/nu13041134
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