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Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System

Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients. We analyzed cerebrospinal fluid (CSF) from 139 patients after the CNS hemorrhage....

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Autores principales: Kelbich, Petr, Hejčl, Aleš, Krejsek, Jan, Radovnický, Tomáš, Matuchová, Inka, Lodin, Jan, Špička, Jan, Sameš, Martin, Procházka, Jan, Hanuljaková, Eva, Vachata, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065782/
https://www.ncbi.nlm.nih.gov/pubmed/33915782
http://dx.doi.org/10.3390/life11040300
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author Kelbich, Petr
Hejčl, Aleš
Krejsek, Jan
Radovnický, Tomáš
Matuchová, Inka
Lodin, Jan
Špička, Jan
Sameš, Martin
Procházka, Jan
Hanuljaková, Eva
Vachata, Petr
author_facet Kelbich, Petr
Hejčl, Aleš
Krejsek, Jan
Radovnický, Tomáš
Matuchová, Inka
Lodin, Jan
Špička, Jan
Sameš, Martin
Procházka, Jan
Hanuljaková, Eva
Vachata, Petr
author_sort Kelbich, Petr
collection PubMed
description Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients. We analyzed cerebrospinal fluid (CSF) from 139 patients after the CNS hemorrhage. We compared 109 survivors (Glasgow Outcome Score (GOS) 5-3) and 30 patients with poor outcomes (GOS 2-1). Statistical evaluations were performed using the Wilcoxon signed-rank test and the Mann–Whitney U test. Almost the same numbers of erythrocytes in both subgroups appeared in days 0–3 (p = 0.927) and a significant increase in patients with GOS 2-1 in days 7–10 after the hemorrhage (p = 0.004) revealed persistence of extravascular blood in the CNS as an adverse factor. We assess 43.3% of patients with GOS 2-1 and only 27.5% of patients with GOS 5-3 with low values of the coefficient of energy balance (KEB < 15.0) in days 0–3 after the hemorrhage as a trend to immediate intensive inflammation in the CNS of patients with poor outcomes. We consider significantly higher concentration of total protein of patients with GOS 2-1 in days 0–3 after hemorrhage (p = 0.008) as the evidence of immediate simultaneously manifested intensive inflammation, swelling of the brain and elevation of intracranial pressure.
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spelling pubmed-80657822021-04-25 Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System Kelbich, Petr Hejčl, Aleš Krejsek, Jan Radovnický, Tomáš Matuchová, Inka Lodin, Jan Špička, Jan Sameš, Martin Procházka, Jan Hanuljaková, Eva Vachata, Petr Life (Basel) Article Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients. We analyzed cerebrospinal fluid (CSF) from 139 patients after the CNS hemorrhage. We compared 109 survivors (Glasgow Outcome Score (GOS) 5-3) and 30 patients with poor outcomes (GOS 2-1). Statistical evaluations were performed using the Wilcoxon signed-rank test and the Mann–Whitney U test. Almost the same numbers of erythrocytes in both subgroups appeared in days 0–3 (p = 0.927) and a significant increase in patients with GOS 2-1 in days 7–10 after the hemorrhage (p = 0.004) revealed persistence of extravascular blood in the CNS as an adverse factor. We assess 43.3% of patients with GOS 2-1 and only 27.5% of patients with GOS 5-3 with low values of the coefficient of energy balance (KEB < 15.0) in days 0–3 after the hemorrhage as a trend to immediate intensive inflammation in the CNS of patients with poor outcomes. We consider significantly higher concentration of total protein of patients with GOS 2-1 in days 0–3 after hemorrhage (p = 0.008) as the evidence of immediate simultaneously manifested intensive inflammation, swelling of the brain and elevation of intracranial pressure. MDPI 2021-04-01 /pmc/articles/PMC8065782/ /pubmed/33915782 http://dx.doi.org/10.3390/life11040300 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kelbich, Petr
Hejčl, Aleš
Krejsek, Jan
Radovnický, Tomáš
Matuchová, Inka
Lodin, Jan
Špička, Jan
Sameš, Martin
Procházka, Jan
Hanuljaková, Eva
Vachata, Petr
Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
title Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
title_full Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
title_fullStr Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
title_full_unstemmed Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
title_short Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
title_sort development of the cerebrospinal fluid in early stage after hemorrhage in the central nervous system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065782/
https://www.ncbi.nlm.nih.gov/pubmed/33915782
http://dx.doi.org/10.3390/life11040300
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