Cargando…
The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma
Patient-derived preclinical models are now a core component of cancer research and have the ability to drastically improve the predictive power of preclinical therapeutic studies. However, their development and maintenance can be challenging, time consuming, and expensive. For neuroblastoma, a devel...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065808/ https://www.ncbi.nlm.nih.gov/pubmed/33808071 http://dx.doi.org/10.3390/jpm11040248 |
_version_ | 1783682427372175360 |
---|---|
author | Tucker, Elizabeth R. George, Sally Angelini, Paola Bruna, Alejandra Chesler, Louis |
author_facet | Tucker, Elizabeth R. George, Sally Angelini, Paola Bruna, Alejandra Chesler, Louis |
author_sort | Tucker, Elizabeth R. |
collection | PubMed |
description | Patient-derived preclinical models are now a core component of cancer research and have the ability to drastically improve the predictive power of preclinical therapeutic studies. However, their development and maintenance can be challenging, time consuming, and expensive. For neuroblastoma, a developmental malignancy of the neural crest, it is possible to establish patient-derived models as xenografts in mice and zebrafish, and as spheroids and organoids in vitro. These varied approaches have contributed to comprehensive packages of preclinical evidence in support of new therapeutics for neuroblastoma. We discuss here the ethical and technical considerations for the creation of patient-derived models of neuroblastoma and how their use can be optimized for the study of tumour evolution and preclinical therapies. We also discuss how neuroblastoma patient-derived models might become avatars for personalised medicine for children with this devastating disease. |
format | Online Article Text |
id | pubmed-8065808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-80658082021-04-25 The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma Tucker, Elizabeth R. George, Sally Angelini, Paola Bruna, Alejandra Chesler, Louis J Pers Med Review Patient-derived preclinical models are now a core component of cancer research and have the ability to drastically improve the predictive power of preclinical therapeutic studies. However, their development and maintenance can be challenging, time consuming, and expensive. For neuroblastoma, a developmental malignancy of the neural crest, it is possible to establish patient-derived models as xenografts in mice and zebrafish, and as spheroids and organoids in vitro. These varied approaches have contributed to comprehensive packages of preclinical evidence in support of new therapeutics for neuroblastoma. We discuss here the ethical and technical considerations for the creation of patient-derived models of neuroblastoma and how their use can be optimized for the study of tumour evolution and preclinical therapies. We also discuss how neuroblastoma patient-derived models might become avatars for personalised medicine for children with this devastating disease. MDPI 2021-03-30 /pmc/articles/PMC8065808/ /pubmed/33808071 http://dx.doi.org/10.3390/jpm11040248 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Review Tucker, Elizabeth R. George, Sally Angelini, Paola Bruna, Alejandra Chesler, Louis The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma |
title | The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma |
title_full | The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma |
title_fullStr | The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma |
title_full_unstemmed | The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma |
title_short | The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma |
title_sort | promise of patient-derived preclinical models to accelerate the implementation of personalised medicine for children with neuroblastoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065808/ https://www.ncbi.nlm.nih.gov/pubmed/33808071 http://dx.doi.org/10.3390/jpm11040248 |
work_keys_str_mv | AT tuckerelizabethr thepromiseofpatientderivedpreclinicalmodelstoacceleratetheimplementationofpersonalisedmedicineforchildrenwithneuroblastoma AT georgesally thepromiseofpatientderivedpreclinicalmodelstoacceleratetheimplementationofpersonalisedmedicineforchildrenwithneuroblastoma AT angelinipaola thepromiseofpatientderivedpreclinicalmodelstoacceleratetheimplementationofpersonalisedmedicineforchildrenwithneuroblastoma AT brunaalejandra thepromiseofpatientderivedpreclinicalmodelstoacceleratetheimplementationofpersonalisedmedicineforchildrenwithneuroblastoma AT cheslerlouis thepromiseofpatientderivedpreclinicalmodelstoacceleratetheimplementationofpersonalisedmedicineforchildrenwithneuroblastoma AT tuckerelizabethr promiseofpatientderivedpreclinicalmodelstoacceleratetheimplementationofpersonalisedmedicineforchildrenwithneuroblastoma AT georgesally promiseofpatientderivedpreclinicalmodelstoacceleratetheimplementationofpersonalisedmedicineforchildrenwithneuroblastoma AT angelinipaola promiseofpatientderivedpreclinicalmodelstoacceleratetheimplementationofpersonalisedmedicineforchildrenwithneuroblastoma AT brunaalejandra promiseofpatientderivedpreclinicalmodelstoacceleratetheimplementationofpersonalisedmedicineforchildrenwithneuroblastoma AT cheslerlouis promiseofpatientderivedpreclinicalmodelstoacceleratetheimplementationofpersonalisedmedicineforchildrenwithneuroblastoma |