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Allosteric Kinase Inhibitors Reshape MEK1 Kinase Activity Conformations in Cells and In Silico
Mutations at different stages of the mitogen-activated protein kinase (MAPK) signaling pathway lead to aberrant activation of the involved protein kinase entities. These oncogenic modifications alter signal propagation which converge on the gatekeeper kinases MEK1/2, transmitting the input signal to...
Autores principales: | Fleischmann, Jakob, Feichtner, Andreas, DeFalco, Louis, Kugler, Valentina, Schwaighofer, Selina, Huber, Roland G, Stefan, Eduard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065916/ https://www.ncbi.nlm.nih.gov/pubmed/33808483 http://dx.doi.org/10.3390/biom11040518 |
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